Matches in SemOpenAlex for { <https://semopenalex.org/work/W196972488> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W196972488 endingPage "5" @default.
- W196972488 startingPage "441" @default.
- W196972488 abstract "The aim of this work was to evaluate and compare the effects of a low calorie diet (1026 kcal), simvastatin and ursodeoxycholic acid administration on biliary lipid secretion and cholic acid kinetics in dieting obese subjects. We studied 6 obese subjects before and after four weeks of a hypocaloric diet alone, after four weeks of diet plus ursodeoxycholic acid (900 mg/day) and after four weeks of diet plus simvastatin (40 mg/day), according to a Latin square design. The cholesterol saturation index was increased after diet alone, significantly reduced with diet plus ursodeoxycholic acid (p < 0.01), and unchanged during simvastatin administration. While the cholesterol output was reduced by all three regimens, diet plus ursodeoxycholic acid caused a significantly greater decrease than diet alone (p < 0.01). Cholic acid synthesis and bile acid secretion were decreased by diet and diet plus simvastatin (p < 0.05), but neither was affected by ursodeoxycholic acid. For cholic acid, all three treatments, but especially diet alone and diet plus simvastatin (p < 0.05), reduced the pool size; all three regimens also increased the turnover rate, but this was significant only for ursodeoxycholic acid (p < 0.01). Our study shows that, in obese patients, a hypocaloric diet reduces cholesterol-holding biliary lipid output and consequently increases the cholesterol saturation index. The addition of simvastatin to a hypocaloric dietary regimen reduces cholesterol secretion, but without variation in bile acid and phospholipid output thus the cholesterol saturation index remains unchanged. When ursodeoxycholic acid is added to the dietary regimen, it reduces cholesterol secretion, while maintaining bile acid output and, thus, lowers the cholesterol saturation index. Unlike simvastatin, ursodeoxycholic acid prevents the drop in cholic acid synthesis induced by a low calorie diet." @default.
- W196972488 created "2016-06-24" @default.
- W196972488 creator A5018793372 @default.
- W196972488 creator A5022435620 @default.
- W196972488 creator A5024285185 @default.
- W196972488 creator A5028205521 @default.
- W196972488 creator A5041353756 @default.
- W196972488 creator A5054816073 @default.
- W196972488 creator A5068796149 @default.
- W196972488 creator A5070769700 @default.
- W196972488 creator A5081995033 @default.
- W196972488 date "1995-10-01" @default.
- W196972488 modified "2023-09-23" @default.
- W196972488 title "Changes in biliary lipid secretion and cholic acid kinetics induced by diet, diet plus simvastatin and diet plus ursodeoxycholic acid in obese subjects." @default.
- W196972488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8775472" @default.
- W196972488 hasPublicationYear "1995" @default.
- W196972488 type Work @default.
- W196972488 sameAs 196972488 @default.
- W196972488 citedByCount "4" @default.
- W196972488 countsByYear W1969724882017 @default.
- W196972488 crossrefType "journal-article" @default.
- W196972488 hasAuthorship W196972488A5018793372 @default.
- W196972488 hasAuthorship W196972488A5022435620 @default.
- W196972488 hasAuthorship W196972488A5024285185 @default.
- W196972488 hasAuthorship W196972488A5028205521 @default.
- W196972488 hasAuthorship W196972488A5041353756 @default.
- W196972488 hasAuthorship W196972488A5054816073 @default.
- W196972488 hasAuthorship W196972488A5068796149 @default.
- W196972488 hasAuthorship W196972488A5070769700 @default.
- W196972488 hasAuthorship W196972488A5081995033 @default.
- W196972488 hasConcept C126322002 @default.
- W196972488 hasConcept C134018914 @default.
- W196972488 hasConcept C2775900799 @default.
- W196972488 hasConcept C2776329913 @default.
- W196972488 hasConcept C2778163477 @default.
- W196972488 hasConcept C2779399885 @default.
- W196972488 hasConcept C2780749602 @default.
- W196972488 hasConcept C2780965833 @default.
- W196972488 hasConcept C71924100 @default.
- W196972488 hasConceptScore W196972488C126322002 @default.
- W196972488 hasConceptScore W196972488C134018914 @default.
- W196972488 hasConceptScore W196972488C2775900799 @default.
- W196972488 hasConceptScore W196972488C2776329913 @default.
- W196972488 hasConceptScore W196972488C2778163477 @default.
- W196972488 hasConceptScore W196972488C2779399885 @default.
- W196972488 hasConceptScore W196972488C2780749602 @default.
- W196972488 hasConceptScore W196972488C2780965833 @default.
- W196972488 hasConceptScore W196972488C71924100 @default.
- W196972488 hasIssue "8" @default.
- W196972488 hasLocation W1969724881 @default.
- W196972488 hasOpenAccess W196972488 @default.
- W196972488 hasPrimaryLocation W1969724881 @default.
- W196972488 hasRelatedWork W196972488 @default.
- W196972488 hasRelatedWork W1984511201 @default.
- W196972488 hasRelatedWork W2028000484 @default.
- W196972488 hasRelatedWork W2079283145 @default.
- W196972488 hasRelatedWork W2087966431 @default.
- W196972488 hasRelatedWork W2123416997 @default.
- W196972488 hasRelatedWork W2170658666 @default.
- W196972488 hasRelatedWork W2428737058 @default.
- W196972488 hasRelatedWork W293977646 @default.
- W196972488 hasRelatedWork W2980905207 @default.
- W196972488 hasVolume "27" @default.
- W196972488 isParatext "false" @default.
- W196972488 isRetracted "false" @default.
- W196972488 magId "196972488" @default.
- W196972488 workType "article" @default.