FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969726504> ?p ?o ?g. }

• W1969726504 endingPage "e1003670" @default.
• W1969726504 startingPage "e1003670" @default.
• W1969726504 abstract "The potato late blight pathogen Phytophthora infestans secretes an array of effector proteins thought to act in its hosts by disarming defences and promoting pathogen colonisation. However, little is known about the host targets of these effectors and how they are manipulated by the pathogen. This work describes the identification of two putative membrane-associated NAC transcription factors (TF) as the host targets of the RxLR effector PITG_03192 (Pi03192). The effector interacts with NAC Targeted by Phytophthora (NTP) 1 and NTP2 at the endoplasmic reticulum (ER) membrane, where these proteins are localised. Transcripts of NTP1 and NTP2 rapidly accumulate following treatment with culture filtrate (CF) from in vitro grown P. infestans, which acts as a mixture of Phytophthora PAMPs and elicitors, but significantly decrease during P. infestans infection, indicating that pathogen activity may prevent their up-regulation. Silencing of NTP1 or NTP2 in the model host plant Nicotiana benthamiana increases susceptibility to P. infestans, whereas silencing of Pi03192 in P. infestans reduces pathogenicity. Transient expression of Pi03192 in planta restores pathogenicity of the Pi03192-silenced line. Moreover, colonisation by the Pi03192-silenced line is significantly enhanced on N. benthamiana plants in which either NTP1 or NTP2 have been silenced. StNTP1 and StNTP2 proteins are released from the ER membrane following treatment with P. infestans CF and accumulate in the nucleus, after which they are rapidly turned over by the 26S proteasome. In contrast, treatment with the defined PAMP flg22 fails to up-regulate NTP1 and NTP2, or promote re-localisation of their protein products to the nucleus, indicating that these events follow perception of a component of CF that appears to be independent of the FLS2/flg22 pathway. Importantly, Pi03192 prevents CF-triggered re-localisation of StNTP1 and StNTP2 from the ER into the nucleus, revealing a novel effector mode-of-action to promote disease progression." @default.
• W1969726504 created "2016-06-24" @default.
• W1969726504 creator A5000924304 @default.
• W1969726504 creator A5036405442 @default.
• W1969726504 creator A5044997276 @default.
• W1969726504 creator A5046661784 @default.
• W1969726504 creator A5057238741 @default.
• W1969726504 creator A5062748038 @default.
• W1969726504 creator A5064322561 @default.
• W1969726504 creator A5074529809 @default.
• W1969726504 creator A5078089571 @default.
• W1969726504 date "2013-10-10" @default.
• W1969726504 modified "2023-10-05" @default.
• W1969726504 title "An RxLR Effector from Phytophthora infestans Prevents Re-localisation of Two Plant NAC Transcription Factors from the Endoplasmic Reticulum to the Nucleus" @default.
• W1969726504 cites W1734845526 @default.
• W1969726504 cites W1969042907 @default.
• W1969726504 cites W1973328229 @default.
• W1969726504 cites W1973573308 @default.
• W1969726504 cites W1974330585 @default.
• W1969726504 cites W1980055662 @default.
• W1969726504 cites W1988987265 @default.
• W1969726504 cites W1995828353 @default.
• W1969726504 cites W2007339777 @default.
• W1969726504 cites W2013128880 @default.
• W1969726504 cites W2016487224 @default.
• W1969726504 cites W2025545161 @default.
• W1969726504 cites W2025882162 @default.
• W1969726504 cites W2027177819 @default.
• W1969726504 cites W2027367097 @default.
• W1969726504 cites W2029835563 @default.
• W1969726504 cites W2034804054 @default.
• W1969726504 cites W2045389027 @default.
• W1969726504 cites W2049336997 @default.
• W1969726504 cites W2051992058 @default.
• W1969726504 cites W2059856607 @default.
• W1969726504 cites W2060687391 @default.
• W1969726504 cites W2066002777 @default.
• W1969726504 cites W2067442982 @default.
• W1969726504 cites W2090595780 @default.
• W1969726504 cites W2096242878 @default.
• W1969726504 cites W2101937491 @default.
• W1969726504 cites W2102370923 @default.
• W1969726504 cites W2102967742 @default.
• W1969726504 cites W2110052739 @default.
• W1969726504 cites W2111119053 @default.
• W1969726504 cites W2115888213 @default.
• W1969726504 cites W2126498993 @default.
• W1969726504 cites W2130497254 @default.
• W1969726504 cites W2132671821 @default.
• W1969726504 cites W2134392367 @default.
• W1969726504 cites W2137871007 @default.
• W1969726504 cites W2138122982 @default.
• W1969726504 cites W2139155185 @default.
• W1969726504 cites W2148657039 @default.
• W1969726504 cites W2149863714 @default.
• W1969726504 cites W2153853387 @default.
• W1969726504 cites W2160506991 @default.
• W1969726504 cites W2160619010 @default.
• W1969726504 cites W2161586272 @default.
• W1969726504 cites W2162024355 @default.
• W1969726504 cites W2162515800 @default.
• W1969726504 cites W2163448850 @default.
• W1969726504 cites W2163800860 @default.
• W1969726504 cites W2165148163 @default.
• W1969726504 cites W2168696662 @default.
• W1969726504 cites W4247005250 @default.
• W1969726504 cites W4294216491 @default.
• W1969726504 doi "https://doi.org/10.1371/journal.ppat.1003670" @default.
• W1969726504 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3795001" @default.
• W1969726504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24130484" @default.
• W1969726504 hasPublicationYear "2013" @default.
• W1969726504 type Work @default.
• W1969726504 sameAs 1969726504 @default.
• W1969726504 citedByCount "189" @default.
• W1969726504 countsByYear W19697265042014 @default.
• W1969726504 countsByYear W19697265042015 @default.
• W1969726504 countsByYear W19697265042016 @default.
• W1969726504 countsByYear W19697265042017 @default.
• W1969726504 countsByYear W19697265042018 @default.
• W1969726504 countsByYear W19697265042019 @default.
• W1969726504 countsByYear W19697265042020 @default.
• W1969726504 countsByYear W19697265042021 @default.
• W1969726504 countsByYear W19697265042022 @default.
• W1969726504 countsByYear W19697265042023 @default.
• W1969726504 crossrefType "journal-article" @default.
• W1969726504 hasAuthorship W1969726504A5000924304 @default.
• W1969726504 hasAuthorship W1969726504A5036405442 @default.
• W1969726504 hasAuthorship W1969726504A5044997276 @default.
• W1969726504 hasAuthorship W1969726504A5046661784 @default.
• W1969726504 hasAuthorship W1969726504A5057238741 @default.
• W1969726504 hasAuthorship W1969726504A5062748038 @default.
• W1969726504 hasAuthorship W1969726504A5064322561 @default.
• W1969726504 hasAuthorship W1969726504A5074529809 @default.
• W1969726504 hasAuthorship W1969726504A5078089571 @default.
• W1969726504 hasBestOaLocation W19697265041 @default.
• W1969726504 hasConcept C104317684 @default.
• W1969726504 hasConcept C119056186 @default.
• W1969726504 hasConcept C158617107 @default.

• next