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• W1969730842 abstract "In dividing animal cells, the centrosome, comprising centrioles and surrounding pericentriolar-material (PCM), is the major interphase microtubule-organizing center (MTOC), arranging a polarized array of microtubules (MTs) that controls cellular architecture. The mouse embryo is a unique setting for investigating the role of centrosomes in MT organization, since the early embryo is acentrosomal, and centrosomes emerge de novo during early cleavages. Here we use embryos from a GFP::CETN2 transgenic mouse to observe the emergence of centrosomes and centrioles in embryos, and show that unfocused acentriolar centrosomes first form in morulae (~16-32-cell stage) and become focused at the blastocyst stage (~64-128 cells) concomitant with the emergence of centrioles. We then used high-resolution microscopy and dynamic tracking of MT growth events in live embryos to examine the impact of centrosome emergence upon interphase MT dynamics. We report that pre-implantation mouse embryos of all stages employ a non-canonical mode of MT organization that generates a complex array of randomly oriented MTs that are preferentially nucleated adjacent to nuclear and plasmalemmal membranes and cell-cell interfaces. Surprisingly, however, cells of the early embryo continue to employ this mode of interphase MT organization even after the emergence of centrosomes. Centrosomes are found at MT-sparse sites and have no detectable impact upon interphase MT dynamics. To our knowledge, the early embryo is unique among proliferating cells in adopting an acentrosomal mode of MT organization despite the presence of centrosomes, revealing that the transition to a canonical mode of interphase MT organization remains incomplete prior to implantation." @default.
• W1969730842 created "2016-06-24" @default.
• W1969730842 creator A5031879767 @default.
• W1969730842 creator A5053704344 @default.
• W1969730842 date "2013-05-15" @default.
• W1969730842 modified "2023-10-15" @default.
• W1969730842 title "A non-canonical mode of microtubule organization operates throughout pre-implantation development in mouse" @default.
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• W1969730842 doi "https://doi.org/10.4161/cc.24755" @default.
• W1969730842 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3680541" @default.
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