FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969731446> ?p ?o ?g. }

• W1969731446 endingPage "596" @default.
• W1969731446 startingPage "591" @default.
• W1969731446 abstract "Treatment with Abl tyrosine kinase inhibitors (TKI) drastically improves the prognosis of chronic myelogenous leukemia (CML) patients. However, quiescent CML cells are insensitive to TKI and can lead to relapse of the disease. Thus, research is needed to elucidate the properties of these quiescent CML cells, including their microenvironment, in order to effectively target them. Hypoxia is known to be a common feature of solid tumors that contributes to therapeutic resistance. Leukemic cells are also able to survive and proliferate in severely hypoxic environments. The hypoxic conditions in the bone marrow (BM) allow leukemic cells that reside there to become insensitive to cell death stimuli. To target leukemic cells in hypoxic conditions, we focused on the hypoxia-selective cytotoxin, Rakicidin A. A previous report showed that Rakicidin A, a natural product produced by the Micromonospora strain, induced hypoxia-selective cytotoxicity in solid tumors. Here, we describe Rakicidin A-induced cell death in hypoxia-adapted (HA)-CML cells with stem cell-like characteristics. Interestingly, apoptosis was induced via caspase-dependent and -independent pathways. In addition, treatment with Rakicidin A in combination with the TKI, imatinib, resulted in synergistic cytotoxicity against HA-CML cells. In conclusion, Rakicidin A is a promising compound for targeting TKI-resistant quiescent CML stem cells in the hypoxic BM environment. (Cancer Sci 2011; 102: 591–596)" @default.
• W1969731446 created "2016-06-24" @default.
• W1969731446 creator A5008116172 @default.
• W1969731446 creator A5022260018 @default.
• W1969731446 creator A5025614828 @default.
• W1969731446 creator A5028603816 @default.
• W1969731446 creator A5035319682 @default.
• W1969731446 creator A5038279230 @default.
• W1969731446 creator A5039456378 @default.
• W1969731446 creator A5042878638 @default.
• W1969731446 creator A5071371446 @default.
• W1969731446 creator A5073870319 @default.
• W1969731446 creator A5077867998 @default.
• W1969731446 date "2010-12-19" @default.
• W1969731446 modified "2023-10-13" @default.
• W1969731446 title "Rakicidin A effectively induces apoptosis in hypoxia adapted Bcr-Abl positive leukemic cells" @default.
• W1969731446 cites W1484043356 @default.
• W1969731446 cites W1964413925 @default.
• W1969731446 cites W1983641075 @default.
• W1969731446 cites W1987239635 @default.
• W1969731446 cites W1990310347 @default.
• W1969731446 cites W1993170286 @default.
• W1969731446 cites W1996830477 @default.
• W1969731446 cites W2000590734 @default.
• W1969731446 cites W2006917576 @default.
• W1969731446 cites W2014292477 @default.
• W1969731446 cites W2017965105 @default.
• W1969731446 cites W2028391959 @default.
• W1969731446 cites W2035565668 @default.
• W1969731446 cites W2040640660 @default.
• W1969731446 cites W2053516011 @default.
• W1969731446 cites W2054442870 @default.
• W1969731446 cites W2055715830 @default.
• W1969731446 cites W2055784390 @default.
• W1969731446 cites W2060725618 @default.
• W1969731446 cites W2060749382 @default.
• W1969731446 cites W2076736727 @default.
• W1969731446 cites W2082580993 @default.
• W1969731446 cites W2089183416 @default.
• W1969731446 cites W2090968770 @default.
• W1969731446 cites W2092803197 @default.
• W1969731446 cites W2094696997 @default.
• W1969731446 cites W2096439168 @default.
• W1969731446 cites W2099296736 @default.
• W1969731446 cites W2103562758 @default.
• W1969731446 cites W2107268345 @default.
• W1969731446 cites W2125096092 @default.
• W1969731446 cites W2130503287 @default.
• W1969731446 cites W2137487800 @default.
• W1969731446 cites W2149468947 @default.
• W1969731446 cites W2154856176 @default.
• W1969731446 cites W2155258039 @default.
• W1969731446 doi "https://doi.org/10.1111/j.1349-7006.2010.01813.x" @default.
• W1969731446 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21166958" @default.
• W1969731446 hasPublicationYear "2010" @default.
• W1969731446 type Work @default.
• W1969731446 sameAs 1969731446 @default.
• W1969731446 citedByCount "31" @default.
• W1969731446 countsByYear W19697314462013 @default.
• W1969731446 countsByYear W19697314462014 @default.
• W1969731446 countsByYear W19697314462015 @default.
• W1969731446 countsByYear W19697314462016 @default.
• W1969731446 countsByYear W19697314462017 @default.
• W1969731446 countsByYear W19697314462018 @default.
• W1969731446 countsByYear W19697314462019 @default.
• W1969731446 countsByYear W19697314462020 @default.
• W1969731446 countsByYear W19697314462021 @default.
• W1969731446 countsByYear W19697314462022 @default.
• W1969731446 countsByYear W19697314462023 @default.
• W1969731446 crossrefType "journal-article" @default.
• W1969731446 hasAuthorship W1969731446A5008116172 @default.
• W1969731446 hasAuthorship W1969731446A5022260018 @default.
• W1969731446 hasAuthorship W1969731446A5025614828 @default.
• W1969731446 hasAuthorship W1969731446A5028603816 @default.
• W1969731446 hasAuthorship W1969731446A5035319682 @default.
• W1969731446 hasAuthorship W1969731446A5038279230 @default.
• W1969731446 hasAuthorship W1969731446A5039456378 @default.
• W1969731446 hasAuthorship W1969731446A5042878638 @default.
• W1969731446 hasAuthorship W1969731446A5071371446 @default.
• W1969731446 hasAuthorship W1969731446A5073870319 @default.
• W1969731446 hasAuthorship W1969731446A5077867998 @default.
• W1969731446 hasBestOaLocation W19697314461 @default.
• W1969731446 hasConcept C109316439 @default.
• W1969731446 hasConcept C121608353 @default.
• W1969731446 hasConcept C126322002 @default.
• W1969731446 hasConcept C178790620 @default.
• W1969731446 hasConcept C185592680 @default.
• W1969731446 hasConcept C190283241 @default.
• W1969731446 hasConcept C202751555 @default.
• W1969731446 hasConcept C203014093 @default.
• W1969731446 hasConcept C2776960273 @default.
• W1969731446 hasConcept C2777583451 @default.
• W1969731446 hasConcept C2778461978 @default.
• W1969731446 hasConcept C2778729363 @default.
• W1969731446 hasConcept C2780007613 @default.
• W1969731446 hasConcept C28328180 @default.
• W1969731446 hasConcept C3019892230 @default.
• W1969731446 hasConcept C31573885 @default.

• next