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• W1969731650 abstract "Background . Obesity is a disorder often accompanied by a heightened state of systemic inflammation and immunoactivation. The present randomized crossover trial aimed to investigate the efficacy of curcumin, a bioactive polyphenol with established anti-inflammatory and immunomodulatory effects, on the serum levels of a panel of cytokines and mediators in obese individuals. Methods . Thirty obese individuals were randomized to receive curcumin at a daily dose of 1 g or a matched placebo for 4 weeks. Following a 2-week wash-out period, each group was assigned to the alternate treatment regimen for another 4 weeks. Serum samples were collected at the start and end of each study period. Serum levels of IL-1 α , IL-1 β , IL-2, IL-4, IL-6, IL-8, IL-10, VEGF, IFN γ , EGF, MCP-1, and TNF α were measured using a multiplex Biochip Array Technology based method. Results . Mean serum IL-1 β (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.042</mml:mn></mml:math>), IL-4 (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.008</mml:mn></mml:math>), and VEGF (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.01</mml:mn></mml:math>) were found to be significantly reduced by curcumin therapy. In contrast, no significant difference was observed in the concentrations of IL-2, IL-6, IL-8, IL-10, IFN γ , EGF, and MCP-1. Conclusions . The findings of the present trial suggested that curcumin may exert immunomodulatory effects via altering the circulating concentrations of IL-1 β , IL-4, and VEGF." @default.
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• W1969731650 date "2014-01-01" @default.
• W1969731650 modified "2023-10-18" @default.
• W1969731650 title "Investigation of the Effects of Curcumin on Serum Cytokines in Obese Individuals: A Randomized Controlled Trial" @default.
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• W1969731650 doi "https://doi.org/10.1155/2014/898361" @default.
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