Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969739712> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W1969739712 endingPage "376" @default.
- W1969739712 startingPage "367" @default.
- W1969739712 abstract "We previously demonstrated that aminoguanidine (AMGN) was able to prevent oxidative modification of LDL. Initially, we thought that this occurred solely because AMGN trapped reactive breakdown products of lipid peroxidation and prevented apoB modification, similar to AMGN's proposed ability to trap reactive glucose intermediates and prevent advanced glycosylation end-product formation. We now demonstrate that AMGN also displays dose-dependent pro-oxidant and antioxidant activity toward LDL. Moderate doses of AMGN (0.05 to 1.0 mmol/L) prevented lipid peroxidation in LDL exposed to copper. AMGN prevented the loss of polyunsaturated fatty acids and delayed or prevented conjugated-diene formation, both of which are sensitive indicators of lipid peroxidation. The same doses of AMGN also prevented apoB modification, a step distal to lipid peroxidation, as evidenced by the ability to (1) prevent fluorescence at 420 nm, (2) block enhanced electrophoretic mobility, and (3) prevent changes leading to enhanced macrophage uptake. Thus, AMGN inhibits LDL modification both by inhibiting lipid peroxidation as well as by trapping reactive breakdown products of lipid peroxidation. It was also demonstrated that for every LDL, there was also a very low dose of AMGN (about 0.01 mmol/L) that actually promoted lipid oxidation and subsequent protein modification. This activity of AMGN could be enhanced by increasing the content of lipid hydroperoxide in the LDL, eg, by aging or radioiodinating the LDL. Conversely, the pro-oxidant activity could be reduced by pretreatment of LDL with ebselen or vitamin E. We propose a mechanism by which AMGN effects pro-oxidant activity toward LDL at very low concentrations and antioxidant activity at higher concentrations and discuss the practical implications of these observations." @default.
- W1969739712 created "2016-06-24" @default.
- W1969739712 creator A5037079092 @default.
- W1969739712 creator A5049658448 @default.
- W1969739712 creator A5076488599 @default.
- W1969739712 creator A5085399860 @default.
- W1969739712 creator A5088504435 @default.
- W1969739712 date "1995-03-01" @default.
- W1969739712 modified "2023-09-26" @default.
- W1969739712 title "Aminoguanidine Has Both Pro-oxidant and Antioxidant Activity Toward LDL" @default.
- W1969739712 cites W1534702626 @default.
- W1969739712 cites W1574445997 @default.
- W1969739712 cites W1775749144 @default.
- W1969739712 cites W1857052429 @default.
- W1969739712 cites W1978146746 @default.
- W1969739712 cites W1984393490 @default.
- W1969739712 cites W1986053342 @default.
- W1969739712 cites W1991726504 @default.
- W1969739712 cites W1995097744 @default.
- W1969739712 cites W1997745709 @default.
- W1969739712 cites W1998614770 @default.
- W1969739712 cites W2005230846 @default.
- W1969739712 cites W2008567943 @default.
- W1969739712 cites W2009933101 @default.
- W1969739712 cites W2013137776 @default.
- W1969739712 cites W2019910142 @default.
- W1969739712 cites W2024542927 @default.
- W1969739712 cites W2032055976 @default.
- W1969739712 cites W2032794311 @default.
- W1969739712 cites W2033988369 @default.
- W1969739712 cites W2045096999 @default.
- W1969739712 cites W2058674735 @default.
- W1969739712 cites W2067182583 @default.
- W1969739712 cites W2071438280 @default.
- W1969739712 cites W2099903211 @default.
- W1969739712 cites W2101736229 @default.
- W1969739712 cites W2109478287 @default.
- W1969739712 cites W2115337518 @default.
- W1969739712 cites W2159098534 @default.
- W1969739712 cites W2168526937 @default.
- W1969739712 cites W2212323528 @default.
- W1969739712 cites W3022864527 @default.
- W1969739712 doi "https://doi.org/10.1161/01.atv.15.3.367" @default.
- W1969739712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7749847" @default.
- W1969739712 hasPublicationYear "1995" @default.
- W1969739712 type Work @default.
- W1969739712 sameAs 1969739712 @default.
- W1969739712 citedByCount "63" @default.
- W1969739712 countsByYear W19697397122012 @default.
- W1969739712 countsByYear W19697397122013 @default.
- W1969739712 countsByYear W19697397122014 @default.
- W1969739712 countsByYear W19697397122015 @default.
- W1969739712 countsByYear W19697397122016 @default.
- W1969739712 countsByYear W19697397122018 @default.
- W1969739712 countsByYear W19697397122019 @default.
- W1969739712 countsByYear W19697397122020 @default.
- W1969739712 countsByYear W19697397122023 @default.
- W1969739712 crossrefType "journal-article" @default.
- W1969739712 hasAuthorship W1969739712A5037079092 @default.
- W1969739712 hasAuthorship W1969739712A5049658448 @default.
- W1969739712 hasAuthorship W1969739712A5076488599 @default.
- W1969739712 hasAuthorship W1969739712A5085399860 @default.
- W1969739712 hasAuthorship W1969739712A5088504435 @default.
- W1969739712 hasBestOaLocation W19697397121 @default.
- W1969739712 hasConcept C185592680 @default.
- W1969739712 hasConcept C2777551382 @default.
- W1969739712 hasConcept C2778004101 @default.
- W1969739712 hasConcept C2780829032 @default.
- W1969739712 hasConcept C55493867 @default.
- W1969739712 hasConceptScore W1969739712C185592680 @default.
- W1969739712 hasConceptScore W1969739712C2777551382 @default.
- W1969739712 hasConceptScore W1969739712C2778004101 @default.
- W1969739712 hasConceptScore W1969739712C2780829032 @default.
- W1969739712 hasConceptScore W1969739712C55493867 @default.
- W1969739712 hasIssue "3" @default.
- W1969739712 hasLocation W19697397121 @default.
- W1969739712 hasLocation W19697397122 @default.
- W1969739712 hasOpenAccess W1969739712 @default.
- W1969739712 hasPrimaryLocation W19697397121 @default.
- W1969739712 hasRelatedWork W1687510487 @default.
- W1969739712 hasRelatedWork W1837235869 @default.
- W1969739712 hasRelatedWork W1993747925 @default.
- W1969739712 hasRelatedWork W2069460849 @default.
- W1969739712 hasRelatedWork W2169892970 @default.
- W1969739712 hasRelatedWork W2332493920 @default.
- W1969739712 hasRelatedWork W2352833908 @default.
- W1969739712 hasRelatedWork W2432277451 @default.
- W1969739712 hasRelatedWork W4212794235 @default.
- W1969739712 hasRelatedWork W2473703414 @default.
- W1969739712 hasVolume "15" @default.
- W1969739712 isParatext "false" @default.
- W1969739712 isRetracted "false" @default.
- W1969739712 magId "1969739712" @default.
- W1969739712 workType "article" @default.