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• W1969745764 abstract "Abstract: Tyrosine aminotransferase (TAT) induction and albumin secretion abilities were examined in rat hepatocytes immobilized within calcium alginate; the immobilized hepatocytes lost these abilities within a week. An attempt was then made to immobilize multicellular spheroids of hepatocytes for the purpose of stabilizing the liver functions. Although it takes at least 4 days to form spheroids in the conventional method using monolayer-cultured cells, in this study we developed a new method for rapid spheroid formation. Isolated hepatocytes were seeded into a polystyrene dish and incubated on a rotary shaker. Hepatocytes started to aggregate after 6 h of the rotation culture, and spheroids approximately 100 μm in diameter formed within 24 h. The immobilized spheroids had higher TAT induction and albumin secretion abilities, which were maintained for a longer time, than the immobilized nonaggregated cells. Further stabilization was observed in immobilized heterospheroids formed in the presence of non-parenchymal liver cells. This method for the rapid formation of spheroids consisting of hepatocytes and non-parenchymal liver cells could be utilized in the construction of a bioartificial liver support system." @default.
• W1969745764 created "2016-06-24" @default.
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• W1969745764 date "2008-11-12" @default.
• W1969745764 modified "2023-09-27" @default.
• W1969745764 title "Rapid Formation of Multicellular Spheroids of Adult Rat Hepatocytes by Rotation Culture and Their Immobilization within Calcium Alginate" @default.
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• W1969745764 doi "https://doi.org/10.1111/j.1525-1594.1993.tb00405.x" @default.
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