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- W1969759937 abstract "Abstract Radioactive neuronal proteins were previously shown to reach tongue (styloglossus) muscle in four waves after 3 H-leucine is applied to the hypoglossal nucleus in rabbits. The present study was concerned with whether, and how, the four waves differed in the proteins transported. Rabbits were killed at the peak periods, 1, 12, 22 and 34 days after administration of precursor, and specimens of medulla, hypoglossal nerve and styloglossus muscle were taken. Specimens of mylohyoid and stylohyoid muscles were also taken for measurement of incorporation of blood-borne precursor. Liquid scintillation counting was done on soluble, insoluble and electro-phoretically separated (acid) protein fractions, permitting the tracing of identifiable proteins from medulla, through nerve to muscle. Findings indicate that: (a) different protein mixtures reach the muscle in the four waves; (b) there are marked discontinuities, with respect to time-course and patterns of radioactivity distribution among the fractions, in the transfer from nerve to muscle as compared to that between nerve segments; and (c) nerve-to-muscle transfer is selective." @default.
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- W1969759937 date "1975-01-01" @default.
- W1969759937 modified "2023-09-24" @default.
- W1969759937 title "Axonal delivery of soluble, insoluble and electrophoretic fractions of neuronal proteins to muscle" @default.
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- W1969759937 doi "https://doi.org/10.1016/0014-4886(75)90037-0" @default.
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