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- W1969760654 abstract "The throughput of protein structure determination has increased greatly over the past decade, thanks to advances in X-ray crystallography and NMR spectroscopy. Protein structure information is now routinely used in vaccine design, and here, Rappuoli and colleagues describe some of the most recent developments in this new field of structural vaccinology. Following the impact of the genomics revolution on vaccine research and the development of reverse vaccinology, it was predicted that another new approach, structure-based antigen design, would become a driving force for vaccine innovation. Now, 5 years on, there are several examples of how structure-based design, or structural vaccinology, can deliver new vaccine antigens that were not possible before. Here, we discuss some of these examples and the contribution of structural vaccinology to our understanding of the protective epitopes of important bacterial and viral pathogens." @default.
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- W1969760654 date "2012-11-16" @default.
- W1969760654 modified "2023-09-27" @default.
- W1969760654 title "Structural vaccinology starts to deliver" @default.
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- W1969760654 doi "https://doi.org/10.1038/nrmicro2893" @default.
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