Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969760870> ?p ?o ?g. }
- W1969760870 endingPage "65" @default.
- W1969760870 startingPage "56" @default.
- W1969760870 abstract "Caloric restriction (CR) is generally linked to lifespan extension in various organisms and may limit age-associated diseases. Processes through which caloric restriction promotes lifespan include obesity-countering weight loss, increased DNA repair, control of ribosomal and telomeric DNA repeats, mitochondrial regulation, activation of antioxidants, and protective autophagy. Several of these protective cellular processes are linked to the suppression of TOR (target of rapamycin) or the activation of sirtuins. In stark contrast, CR fails to extend or even shortens lifespan in certain settings. CR-dependent lifespan shortening is linked to weight loss in the non-obese, mitochondrial hyperactivity, genomic inflexibility, and several other processes. Deciphering the balance between positive and negative effects of CR is critical to understanding its ultimate impact on aging. This knowledge is especially needed in order to fulfil the promise of using CR or its mimetic drugs to counteract age-associated diseas..." @default.
- W1969760870 created "2016-06-24" @default.
- W1969760870 creator A5025118335 @default.
- W1969760870 creator A5077303669 @default.
- W1969760870 date "2014-01-01" @default.
- W1969760870 modified "2023-10-11" @default.
- W1969760870 title "The fine line between lifespan extension and shortening in response to caloric restriction" @default.
- W1969760870 cites W1542109194 @default.
- W1969760870 cites W1560262724 @default.
- W1969760870 cites W1901983160 @default.
- W1969760870 cites W1966132436 @default.
- W1969760870 cites W1967588638 @default.
- W1969760870 cites W1970130845 @default.
- W1969760870 cites W1973858241 @default.
- W1969760870 cites W1975648577 @default.
- W1969760870 cites W1976635482 @default.
- W1969760870 cites W1977244638 @default.
- W1969760870 cites W1977852723 @default.
- W1969760870 cites W1980033290 @default.
- W1969760870 cites W1980878904 @default.
- W1969760870 cites W1985244614 @default.
- W1969760870 cites W1985977889 @default.
- W1969760870 cites W1987738803 @default.
- W1969760870 cites W1987769185 @default.
- W1969760870 cites W1989228555 @default.
- W1969760870 cites W1994067034 @default.
- W1969760870 cites W1994207151 @default.
- W1969760870 cites W1994305081 @default.
- W1969760870 cites W1994899551 @default.
- W1969760870 cites W1995171819 @default.
- W1969760870 cites W1998494964 @default.
- W1969760870 cites W1998663807 @default.
- W1969760870 cites W2001327293 @default.
- W1969760870 cites W2004442859 @default.
- W1969760870 cites W2008821714 @default.
- W1969760870 cites W2009035792 @default.
- W1969760870 cites W2009332336 @default.
- W1969760870 cites W2014892893 @default.
- W1969760870 cites W2016311733 @default.
- W1969760870 cites W2016797892 @default.
- W1969760870 cites W2017117976 @default.
- W1969760870 cites W2020705004 @default.
- W1969760870 cites W2021512852 @default.
- W1969760870 cites W2022572059 @default.
- W1969760870 cites W2023448902 @default.
- W1969760870 cites W2026398820 @default.
- W1969760870 cites W2030732918 @default.
- W1969760870 cites W2032613220 @default.
- W1969760870 cites W2033440477 @default.
- W1969760870 cites W2036519228 @default.
- W1969760870 cites W2037211598 @default.
- W1969760870 cites W2037349364 @default.
- W1969760870 cites W2041811438 @default.
- W1969760870 cites W2044430178 @default.
- W1969760870 cites W2045611938 @default.
- W1969760870 cites W2048376696 @default.
- W1969760870 cites W2051658606 @default.
- W1969760870 cites W2051945197 @default.
- W1969760870 cites W2052093947 @default.
- W1969760870 cites W2053493267 @default.
- W1969760870 cites W2054494035 @default.
- W1969760870 cites W2055634544 @default.
- W1969760870 cites W2055807959 @default.
- W1969760870 cites W2058050995 @default.
- W1969760870 cites W2058632246 @default.
- W1969760870 cites W2058664192 @default.
- W1969760870 cites W2060535344 @default.
- W1969760870 cites W2065245671 @default.
- W1969760870 cites W2066762257 @default.
- W1969760870 cites W2066834513 @default.
- W1969760870 cites W2067395327 @default.
- W1969760870 cites W2069526848 @default.
- W1969760870 cites W2071062834 @default.
- W1969760870 cites W2072727556 @default.
- W1969760870 cites W2074643862 @default.
- W1969760870 cites W2074740541 @default.
- W1969760870 cites W2074974899 @default.
- W1969760870 cites W2075612822 @default.
- W1969760870 cites W2077165816 @default.
- W1969760870 cites W2078903854 @default.
- W1969760870 cites W2080094749 @default.
- W1969760870 cites W2080286047 @default.
- W1969760870 cites W2082182268 @default.
- W1969760870 cites W2082649271 @default.
- W1969760870 cites W2083556426 @default.
- W1969760870 cites W2084708023 @default.
- W1969760870 cites W2088381487 @default.
- W1969760870 cites W2090067193 @default.
- W1969760870 cites W2091614341 @default.
- W1969760870 cites W2098812571 @default.
- W1969760870 cites W2099547258 @default.
- W1969760870 cites W2101580126 @default.
- W1969760870 cites W2103416697 @default.
- W1969760870 cites W2104438296 @default.
- W1969760870 cites W2109716633 @default.
- W1969760870 cites W2110177454 @default.
- W1969760870 cites W2111322904 @default.
- W1969760870 cites W2121966499 @default.