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- W1969762016 abstract "The kinetic characteristics of Mg2+ and substrate (Mg-ATP) utilization by renal cortical plasma membrane adenylate cyclase were investigated in the presence or absence of PTH and with either guanosine 5′-triphosphate (GTP) or guanyl-5′-yl-imidodiphosphate [Gpp(NH)p] included in the reaction mixture. Basal- and PTH-stimulated adenylate cyclase activity was found to be dependent on Mg2+. Gpp(NH)p, but not GTP, resulted in hysteretic activation of renal cortical adenylate clase which was abolished with PTH activation. Gpp(NH)p augmented basal adenylate cyclase activity approximately 5-fold greater than GTP. PTH caused a 2-fold increase in activity over basal in the presence of 0.01 mm Gpp(NH)p but a 10-fold increase was seen in the presence of 0.01 mm and 0.10 mm GTP. Maximum velocity (Vmax) under basal conditions and with PTH activation was similar regardless of which guanine nucleotide was included in the reaction mixture. Linear regression analysis of cAMP accumulation with varying Mg2+ concentrations (0...." @default.
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- W1969762016 date "1983-10-01" @default.
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- W1969762016 title "Renal Cortical Adenylate Cyclase: Characterization of Magnesium Activation*" @default.
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- W1969762016 doi "https://doi.org/10.1210/endo-113-4-1348" @default.
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