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- W1969763672 abstract "A measles virus carrier cell line in Lu 106 cells is described. In most passages more than 90% of infected cells exhibited a hemadsorbing capacity. The virus products released from the carrier cells mainly were non-infectious components. After equilibrium centrifugation in CsCl gradients the occurrence of a relative increase in hemagglutinin of lower density, 1.21 to 1.20 g./cc., was frequently found. The carrier cells were completely resistant to superinfection with the homologous type of virus. Furthermore the plating efficiency of a virulent strain of poliovirus type 1 on carrier cells as compared to normal cells was markedly reduced. However, no interference was demonstrable with Sendai, vaccinia and adenovirus type 3. No Interferon was detectable in concentrated material. No induction occurred when the carrier cells were propagated in the presence of 0.05μg. actinomycin per ml. A reduction in the temperature of incubation from 37° C to 33° C caused a gradually increasing occurrence of cytopathic changes eventually leading to a complete destruction of the monolayer of carrier cells. It is concluded that the carrier state presumably is dependent upon factors other than or additional to a production of Interferon." @default.
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- W1969763672 date "1967-06-01" @default.
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- W1969763672 title "A carrier cell line of measles virus in Lu 106 cells" @default.
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- W1969763672 doi "https://doi.org/10.1007/bf01241275" @default.
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