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• W1969763715 abstract "No AccessJournal of UrologyPediatric Urology1 Jun 2005THE EFFECT OF OXYBUTYNIN TREATMENT ON COGNITION IN CHILDREN WITH DIURNAL INCONTINENCE BARBARA R. SOMMER, RUTH O’HARA, NUSHA ASKARI, HELENA C. KRAEMER, and WILLIAM A. KENNEDY BARBARA R. SOMMERBARBARA R. SOMMER More articles by this author , RUTH O’HARARUTH O’HARA More articles by this author , NUSHA ASKARINUSHA ASKARI More articles by this author , HELENA C. KRAEMERHELENA C. KRAEMER More articles by this author , and WILLIAM A. KENNEDYWILLIAM A. KENNEDY More articles by this author View All Author Informationhttps://doi.org/10.1097/01.ju.0000157685.83573.79AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Oxybutynin is a powerful anticholinergic drug already known to impair cognition in the elderly. The impact of this drug on cognitive functioning in the pediatric population is unknown. We report the results of a study designed to assess the effect of oxybutynin on cognitive function in children. Materials and Methods: A total of 25 patients presenting with the primary symptom of daytime enuresis were recruited for this nonrandomized trial. All subjects initially received 4 weeks of behavior modification, followed by an additional 4 weeks of behavior modification either alone or with oxybutynin for continued treatment of enuresis. Neuropsychological testing was performed at baseline (4 weeks) and after additional therapy (8 weeks). Results: Patient demographics included a male-to-female ratio of 11:14 and a mean age of 7.2 ± 1.8 years. A total of 10 patients were assigned to the control group receiving behavior modification, and 15 patients were assigned to the treatment group receiving behavior modification plus oxybutynin. The oxybutynin treated patients had a lower overall performance at baseline pretreatment testing. However, performance in this group improved following treatment with oxybutynin. Conclusions: Oxybutynin, a commonly used pharmacological agent in pediatric urology, was not associated with cognitive impairment following treatment. However, we observed lower baseline cognitive functioning in patients whose parents chose oxybutynin over behavior modification alone. This finding may represent a selection bias. However, it also supports the need for a multidisciplinary approach to the treatment of patients with dysfunctional voiding, as some may have cognitive difficulties that have not previously been explored. References 1 : Urodynamic evaluation in children. In: Pediatric Urology. Edited by . Baltimore: Williams & Wilkins1987: 114. chapt 6. Google Scholar 2 : Influences of trospium chloride and oxybutynin on quantitative EEG in healthy volunteers. Eur J Clin Pharmacol1994; 47: 337. 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Link, Google Scholar Departments of Psychiatry and Urology (WAK), Stanford University School of Medicine, Stanford, California© 2005 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited bySammour Z, Hisano M, de Bessa J, Bruschini H, Nahas W, Srougi M and Gomes C (2020) Longitudinal Improvement of Lower Urinary Tract Symptoms in Williams-Beuren SyndromeJournal of Urology, VOL. 205, NO. 5, (1476-1482), Online publication date: 1-May-2021.Van Batavia J (2017) Editorial CommentJournal of Urology, VOL. 198, NO. 4, (936-936), Online publication date: 1-Oct-2017.Austin P (2013) Symptoms and Side Effects: Delicate Balance in the Management of Patients with Neurogenic BladderJournal of Urology, VOL. 190, NO. 6, (1974-1975), Online publication date: 1-Dec-2013.Sammour Z, Gomes C, de Bessa J, Pinheiro M, Kim C, Honjo R, Trigo-Rocha F, Bruschini H and Srougi M (2012) The Effects of Oxybutynin on Urinary Symptoms in Children with Williams-Beuren SyndromeJournal of Urology, VOL. 188, NO. 1, (253-257), Online publication date: 1-Jul-2012.Bolduc S, Moore K, Nadeau G, Lebel S, Lamontagne P and Hamel M (2010) Prospective Open Label Study of Solifenacin for Overactive Bladder in ChildrenJournal of Urology, VOL. 184, NO. 4S, (1668-1673), Online publication date: 1-Oct-2010.Bolduc S, Moore K, Lebel S, Lamontagne P and Hamel M (2009) Double Anticholinergic Therapy for Refractory Overactive BladderJournal of Urology, VOL. 182, NO. 4S, (2033-2039), Online publication date: 1-Oct-2009.Chertin B, Koulikov D, Abu-Arafeh W, Mor Y, Shenfeld O and Farkas A (2007) Treatment of Nocturnal Enuresis in Children With Attention Deficit Hyperactivity DisorderJournal of Urology, VOL. 178, NO. 4S, (1744-1747), Online publication date: 1-Oct-2007. Volume 173Issue 6June 2005Page: 2125-2127 Advertisement Copyright & Permissions© 2005 by American Urological Association, Inc.Keywordsenuresisurination disorderscognitionpediatricsoxybutyninMetricsAuthor Information BARBARA R. SOMMER More articles by this author RUTH O’HARA More articles by this author NUSHA ASKARI More articles by this author HELENA C. KRAEMER More articles by this author WILLIAM A. KENNEDY More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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