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• W1969766619 endingPage "e12354" @default.
• W1969766619 startingPage "e12354" @default.
• W1969766619 abstract "Apicomplexan parasites replicate by varied and unusual processes where the typically eukaryotic expansion of cellular components and chromosome cycle are coordinated with the biosynthesis of parasite-specific structures essential for transmission.Here we describe the global cell cycle transcriptome of the tachyzoite stage of Toxoplasma gondii. In dividing tachyzoites, more than a third of the mRNAs exhibit significant cyclical profiles whose timing correlates with biosynthetic events that unfold during daughter parasite formation. These 2,833 mRNAs have a bimodal organization with peak expression occurring in one of two transcriptional waves that are bounded by the transition into S phase and cell cycle exit following cytokinesis. The G1-subtranscriptome is enriched for genes required for basal biosynthetic and metabolic functions, similar to most eukaryotes, while the S/M-subtranscriptome is characterized by the uniquely apicomplexan requirements of parasite maturation, development of specialized organelles, and egress of infectious daughter cells. Two dozen AP2 transcription factors form a series through the tachyzoite cycle with successive sharp peaks of protein expression in the same timeframes as their mRNA patterns, indicating that the mechanisms responsible for the timing of protein delivery might be mediated by AP2 domains with different promoter recognition specificities.Underlying each of the major events in apicomplexan cell cycles, and many more subordinate actions, are dynamic changes in parasite gene expression. The mechanisms responsible for cyclical gene expression timing are likely crucial to the efficiency of parasite replication and may provide new avenues for interfering with parasite growth." @default.
• W1969766619 created "2016-06-24" @default.
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• W1969766619 date "2010-08-26" @default.
• W1969766619 modified "2023-10-10" @default.
• W1969766619 title "Coordinated Progression through Two Subtranscriptomes Underlies the Tachyzoite Cycle of Toxoplasma gondii" @default.
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• W1969766619 doi "https://doi.org/10.1371/journal.pone.0012354" @default.
• W1969766619 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2928733" @default.
• W1969766619 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20865045" @default.
• W1969766619 hasPublicationYear "2010" @default.
• W1969766619 type Work @default.

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