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- W1969768261 abstract "To determine which dosage of estrogen might provide physiological replacement and also avoid possible harmful side effects, 21 postmenopausal women were studied before and after the oral administration of conjugated equine estrogens. The dosages studied were 0.15, 0.30, 0.625, and1.25 mg/day, with each being given for 6 weeks. Fifteen premenopausal women ere also studied, and their values were presumed to reflect normal physiological function Variable responses of the different biochemical and biological markers of the action of estrogen were observed. Both LH and FS levels showed stepwise decreases with increasing amounts of estrogen, but even 1.25 mg;/day did notsuppress these hormones to the range found in premenopausawomen, suggesting a subphysiological response. The lower dosages of conjugated estrogen had minimal effects on vaginal cytology, withonly the 1.25-mg dose changing the maturation index to values similar to those found in premenopausa subjects. The 0.3-mg dose of conjugated estrogen was the lowest amount that resulted in a significant reduction (P <0.05) of the urinary calcium to creatinine ratio (an index of bone resorption).Liver protein synthesis was the most sensitive parameter to the action of estrogen. Hepatic responses were variable depending on which protein was assessed. These data indicate that the oral administration of conjugated equine estrogens results in inconsistent effects. All doses exerted subphysiological, physiological, and pharmacological responses at the different sites of action." @default.
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- W1969768261 date "1980-09-01" @default.
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- W1969768261 title "Biological Effects of Various Doses of Conjugated Equine Estrogens in Postmenopausal Women*" @default.
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- W1969768261 doi "https://doi.org/10.1210/jcem-51-3-620" @default.
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