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• W1969772259 abstract "The distribution of the Ki-67, bcl-2 and caspase-3 proteins was immunohistochemically analyzed in the developing human upper jaw (5th–10th gestational weeks). During this period, proliferative activity gradually decreased from higher levels at the earliest stages (50–52%) to lower levels, both in the jaw ectomesenchyme and in the epithelium. The highest expression of bcl-2 protein was found in the epithelium and ectomesenchyme of areas displaying lower rates of cell proliferation. High levels of caspase-3 protein were detected during the earliest stages of jaw development, indicating an important role for apoptosis in morphogenesis of early derivatives of the maxillary prominences. The number of Ki-67, bcl-2 and caspase-3 positive cells changed in a temporally and spatially restricted manner, coincidently with upper jaw differentiation. While apoptosis might control cell number, bcl-2 could act in suppression of apoptosis and enhancement of cell differentiation. A fine balance between cell proliferation (Ki-67), death (caspase-3) and cell survival (bcl-2) characterized early human upper jaw development. A rise in the number of apoptotic cells always temporally coincided with the decrease in number of surviving bcl-2 positive cells within the palatal region. Therefore, the upper jaw development seems to be controlled by the precisely defined expression of genes for proliferation, apoptosis and cell survival." @default.
• W1969772259 created "2016-06-24" @default.
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• W1969772259 date "2011-09-01" @default.
• W1969772259 modified "2023-09-27" @default.
• W1969772259 title "Developmental patterns of Ki-67, bcl-2 and caspase-3 proteins expression in the human upper jaw" @default.
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• W1969772259 doi "https://doi.org/10.1016/j.acthis.2010.05.005" @default.
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