FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969773420> ?p ?o ?g. }

• W1969773420 endingPage "23" @default.
• W1969773420 startingPage "14" @default.
• W1969773420 abstract "We determined the effects of peroxynitrite (ONOO−) on cardiac myosin, actin, and thin filaments in order to more clearly understand the impact of this reactive compound in ischemia/reperfusion injury and heart failure. Actin filaments, native thin filaments, and α-cardiac myosin from rat hearts were exposed to ONOO− in the presence of 2 mM bicarbonate. Filament velocities over myosin, calcium sensitivity, and relative force generated by myosin were assessed in an in vitro motility assay in the absence of reducing agents. ONOO− concentrations ≥ 10 μM significantly reduced the velocities of thin filaments or bare actin filaments over α-cardiac myosin when any of these proteins were exposed individually. These functional deficits were linearly related to the degree of tyrosine nitration, with myosin being the most sensitive. However, at 10 μM ONOO− the calcium sensitivity of thin filaments remained unchanged. Cotreatment of myosin and thin filaments, analogous to the in vivo situation, resulted in a significantly greater functional deficit. The load supported by myosin after ONOO− exposure was estimated using mixtures experiments to be increased threefold. These data suggest that nitration of myofibrillar proteins can contribute to cardiac contractile dysfunction in pathologic states in which ONOO− is liberated." @default.
• W1969773420 created "2016-06-24" @default.
• W1969773420 creator A5013069120 @default.
• W1969773420 creator A5064928547 @default.
• W1969773420 creator A5089470316 @default.
• W1969773420 creator A5091692538 @default.
• W1969773420 date "2008-01-01" @default.
• W1969773420 modified "2023-10-14" @default.
• W1969773420 title "Peroxynitrite inhibits myofibrillar protein function in an in vitro assay of motility" @default.
• W1969773420 cites W1569797408 @default.
• W1969773420 cites W1583277079 @default.
• W1969773420 cites W1634601902 @default.
• W1969773420 cites W1749029280 @default.
• W1969773420 cites W1964876495 @default.
• W1969773420 cites W1975482510 @default.
• W1969773420 cites W1975594408 @default.
• W1969773420 cites W1977051351 @default.
• W1969773420 cites W1990792990 @default.
• W1969773420 cites W1991956478 @default.
• W1969773420 cites W1999589434 @default.
• W1969773420 cites W2010273334 @default.
• W1969773420 cites W2011095668 @default.
• W1969773420 cites W2012992792 @default.
• W1969773420 cites W2016849688 @default.
• W1969773420 cites W2023677185 @default.
• W1969773420 cites W2026836008 @default.
• W1969773420 cites W2029827227 @default.
• W1969773420 cites W2030966306 @default.
• W1969773420 cites W2037915957 @default.
• W1969773420 cites W2039388361 @default.
• W1969773420 cites W2042629182 @default.
• W1969773420 cites W2043617391 @default.
• W1969773420 cites W2050206397 @default.
• W1969773420 cites W2056677653 @default.
• W1969773420 cites W2058086138 @default.
• W1969773420 cites W2058173393 @default.
• W1969773420 cites W2058497997 @default.
• W1969773420 cites W2064935758 @default.
• W1969773420 cites W2065169761 @default.
• W1969773420 cites W2065332435 @default.
• W1969773420 cites W2068680802 @default.
• W1969773420 cites W2069529258 @default.
• W1969773420 cites W2076911700 @default.
• W1969773420 cites W2082062242 @default.
• W1969773420 cites W2091954160 @default.
• W1969773420 cites W2093814798 @default.
• W1969773420 cites W2095798342 @default.
• W1969773420 cites W2096668802 @default.
• W1969773420 cites W2098445463 @default.
• W1969773420 cites W2099159245 @default.
• W1969773420 cites W2112893975 @default.
• W1969773420 cites W2115023961 @default.
• W1969773420 cites W2118905867 @default.
• W1969773420 cites W2120620942 @default.
• W1969773420 cites W2135289666 @default.
• W1969773420 cites W2138382873 @default.
• W1969773420 cites W2144872573 @default.
• W1969773420 cites W2152440427 @default.
• W1969773420 cites W2157230023 @default.
• W1969773420 cites W2170295209 @default.
• W1969773420 cites W2269567418 @default.
• W1969773420 cites W2313146984 @default.
• W1969773420 cites W2316918019 @default.
• W1969773420 cites W383489959 @default.
• W1969773420 cites W4234012592 @default.
• W1969773420 cites W789458867 @default.
• W1969773420 doi "https://doi.org/10.1016/j.freeradbiomed.2007.09.004" @default.
• W1969773420 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2180163" @default.
• W1969773420 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18045543" @default.
• W1969773420 hasPublicationYear "2008" @default.
• W1969773420 type Work @default.
• W1969773420 sameAs 1969773420 @default.
• W1969773420 citedByCount "59" @default.
• W1969773420 countsByYear W19697734202012 @default.
• W1969773420 countsByYear W19697734202013 @default.
• W1969773420 countsByYear W19697734202014 @default.
• W1969773420 countsByYear W19697734202015 @default.
• W1969773420 countsByYear W19697734202016 @default.
• W1969773420 countsByYear W19697734202017 @default.
• W1969773420 countsByYear W19697734202018 @default.
• W1969773420 countsByYear W19697734202019 @default.
• W1969773420 countsByYear W19697734202021 @default.
• W1969773420 countsByYear W19697734202022 @default.
• W1969773420 countsByYear W19697734202023 @default.
• W1969773420 crossrefType "journal-article" @default.
• W1969773420 hasAuthorship W1969773420A5013069120 @default.
• W1969773420 hasAuthorship W1969773420A5064928547 @default.
• W1969773420 hasAuthorship W1969773420A5089470316 @default.
• W1969773420 hasAuthorship W1969773420A5091692538 @default.
• W1969773420 hasBestOaLocation W19697734202 @default.
• W1969773420 hasConcept C12554922 @default.
• W1969773420 hasConcept C125705527 @default.
• W1969773420 hasConcept C178790620 @default.
• W1969773420 hasConcept C181199279 @default.
• W1969773420 hasConcept C185592680 @default.
• W1969773420 hasConcept C2778784160 @default.
• W1969773420 hasConcept C2780795997 @default.
• W1969773420 hasConcept C519063684 @default.

• next