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- W1969786656 abstract "We report herein a luminescent switch-on label-free G-quadruplex-based assay for the rapid and sensitive detection of polymerase proofreading activity using a novel iridium(III) complex as a G-quadruplex-selective probe. The interaction of the iridium(III) complex with the G-quadruplex motif facilitates the highly sensitive switch-on detection of polymerase proofreading activity. Using T4 DNA polymerase (T4 pol) as a model enzyme, the assay achieved high sensitivity and selectivity for T4 pol over other tested enzymes." @default.
- W1969786656 created "2016-06-24" @default.
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- W1969786656 date "2013-12-01" @default.
- W1969786656 modified "2023-10-16" @default.
- W1969786656 title "A highly sensitive G-quadruplex-based luminescent switch-on probe for the detection of polymerase 3′–5′ proofreading activity" @default.
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- W1969786656 doi "https://doi.org/10.1016/j.ymeth.2013.05.017" @default.
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