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- W1969797620 abstract "In homozygous sickle cell disease (SCD), decreased serum Vitamin E is present. Excessive transfusions may lead to iron overload. We hypothesised a relationship between the two and found that Vitamin E type antioxidant capacity was significantly lower in 30 SCD patients than in 30 age- and sex-matched controls (P < 0.001). Antioxidant capacity was lower in 10 transfused patients compared with 20 non-transfused patients (P < 0.001). Transfusional iron overload in SCD may increase the potential for oxidative damage, and low antioxidant capacity may compound this effect." @default.
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- W1969797620 date "2002-01-18" @default.
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- W1969797620 title "Reduced vitamin E antioxidant capacity in sickle cell disease is related to transfusion status but not to sickle crisis" @default.
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- W1969797620 doi "https://doi.org/10.1002/ajh.10033" @default.
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