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• W1969813909 abstract "Abstract: Background: To assess the efficacy of 24‐ or 48‐week peginterferon/ribavirin treatment of Taiwanese patients with chronic hepatitis C virus genotype‐1b (HCV‐1b) infection, and to identify subgroups of patients in whom the 48‐week treatment has benefits. Methods : We assigned 60 patients receiving peginterferon‐α‐2b (80–100 mcg/week) plus ribavirin (1000–1200 mg/day), depending on body weight, for 24 or 48 weeks, with a 3:1 randomization ratio. Results : The sustained virological response (SVR) rate was significantly higher in the 48‐week (80.0%, 12/15) than in the 24‐week group (48.9%, 22/45, P <0.05). The 60 patients were classified into two subgroups according to the presence of unfavorable baseline predictors: viral loads ≥400 000 IU/ml or a hepatic fibrosis score of 3–4. In 19 patients without an unfavorable predictor, the SVR rate was comparable in the 24‐week (78.6%) and 48‐week (75.0%) groups; in patients with either unfavorable predictors, the SVR rate was significantly higher in the 48‐week (81.1%, 9/11) than in the 24‐week group (36.7%, 11/30, P =0.015). The discontinuation rate was significantly higher in the 48‐week (20.0%, 3/15) than in the 24‐week group (2.2%, 1/45, P <0.05). Conclusion : A 48‐week course of peginterferon‐α‐2b/ribavirin was more effective than a 24‐week course in Taiwanese HCV‐1b patients, mainly in those with high viral loads and/or advanced hepatic fibrosis." @default.
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• W1969813909 date "2005-11-18" @default.
• W1969813909 modified "2023-10-16" @default.
• W1969813909 title "A randomized trial of 24‐ vs. 48‐week courses of PEG interferon α‐2b plus ribavirin for genotype‐1b‐infected chronic hepatitis C patients: a pilot study in Taiwan" @default.
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• W1969813909 doi "https://doi.org/10.1111/j.1478-3231.2005.01196.x" @default.
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