FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969823770> ?p ?o ?g. }

• W1969823770 endingPage "1407" @default.
• W1969823770 startingPage "1394" @default.
• W1969823770 abstract "Understanding the impact of active dendritic properties on network activity in vivo has so far been restricted to studies in anesthetized animals. However, to date no study has been made to determine the direct effect of the anesthetics themselves on dendritic properties. Here, we investigated the effects of three types of anesthetics commonly used for animal experiments (urethane, pentobarbital and ketamine/xylazine). We investigated the generation of calcium spikes, the propagation of action potentials (APs) along the apical dendrite and the somatic firing properties in the presence of anesthetics in vitro using dual somatodendritic whole cell recordings. Calcium spikes were evoked with dendritic current injection and high-frequency trains of APs at the soma. Surprisingly, we found that the direct actions of anesthetics on calcium spikes were very different. Two anesthetics (urethane and pentobarbital) suppressed dendritic calcium spikes in vitro, whereas a mixture of ketamine and xylazine enhanced them. Propagation of spikes along the dendrite was not significantly affected by any of the anesthetics but there were various changes in somatic firing properties that were highly dependent on the anesthetic. Last, we examined the effects of anesthetics on calcium spike initiation and duration in vivo using high-frequency trains of APs generated at the cell body. We found the same anesthetic-dependent direct effects in addition to an overall reduction in dendritic excitability in anesthetized rats with all three anesthetics compared with the slice preparation." @default.
• W1969823770 created "2016-06-24" @default.
• W1969823770 creator A5003823818 @default.
• W1969823770 creator A5078925464 @default.
• W1969823770 date "2008-03-01" @default.
• W1969823770 modified "2023-10-15" @default.
• W1969823770 title "Effect of Common Anesthetics on Dendritic Properties in Layer 5 Neocortical Pyramidal Neurons" @default.
• W1969823770 cites W1600620818 @default.
• W1969823770 cites W1716632673 @default.
• W1969823770 cites W1797134060 @default.
• W1969823770 cites W1828079137 @default.
• W1969823770 cites W1898999540 @default.
• W1969823770 cites W1946447667 @default.
• W1969823770 cites W1966087347 @default.
• W1969823770 cites W1966692467 @default.
• W1969823770 cites W1967086564 @default.
• W1969823770 cites W1970328639 @default.
• W1969823770 cites W1970339131 @default.
• W1969823770 cites W1971366695 @default.
• W1969823770 cites W1973837156 @default.
• W1969823770 cites W1978989391 @default.
• W1969823770 cites W1979514279 @default.
• W1969823770 cites W1986714849 @default.
• W1969823770 cites W1986731926 @default.
• W1969823770 cites W1987832351 @default.
• W1969823770 cites W1988185095 @default.
• W1969823770 cites W1988923854 @default.
• W1969823770 cites W1991751117 @default.
• W1969823770 cites W2000769553 @default.
• W1969823770 cites W2001110297 @default.
• W1969823770 cites W2010600097 @default.
• W1969823770 cites W2013035507 @default.
• W1969823770 cites W2016321438 @default.
• W1969823770 cites W2017569276 @default.
• W1969823770 cites W2028884770 @default.
• W1969823770 cites W2029971543 @default.
• W1969823770 cites W2039173985 @default.
• W1969823770 cites W2054797412 @default.
• W1969823770 cites W2057613746 @default.
• W1969823770 cites W2058346250 @default.
• W1969823770 cites W2064647605 @default.
• W1969823770 cites W2069966134 @default.
• W1969823770 cites W2072150567 @default.
• W1969823770 cites W2077993124 @default.
• W1969823770 cites W2079453253 @default.
• W1969823770 cites W2081025398 @default.
• W1969823770 cites W2085649209 @default.
• W1969823770 cites W2090305457 @default.
• W1969823770 cites W2102246612 @default.
• W1969823770 cites W2106641616 @default.
• W1969823770 cites W2107731277 @default.
• W1969823770 cites W2109086034 @default.
• W1969823770 cites W2120176506 @default.
• W1969823770 cites W2120685116 @default.
• W1969823770 cites W2121725256 @default.
• W1969823770 cites W2121875250 @default.
• W1969823770 cites W2124798190 @default.
• W1969823770 cites W2127562971 @default.
• W1969823770 cites W2133406691 @default.
• W1969823770 cites W2140504089 @default.
• W1969823770 cites W2143072133 @default.
• W1969823770 cites W2145949904 @default.
• W1969823770 cites W2148082810 @default.
• W1969823770 cites W2151488696 @default.
• W1969823770 cites W2154748045 @default.
• W1969823770 cites W2161577728 @default.
• W1969823770 cites W2166138822 @default.
• W1969823770 cites W2166454523 @default.
• W1969823770 cites W2166837804 @default.
• W1969823770 cites W2168065223 @default.
• W1969823770 cites W2168553451 @default.
• W1969823770 cites W2169478814 @default.
• W1969823770 cites W2186371834 @default.
• W1969823770 cites W2316386808 @default.
• W1969823770 cites W4236767446 @default.
• W1969823770 cites W4322702939 @default.
• W1969823770 doi "https://doi.org/10.1152/jn.01126.2007" @default.
• W1969823770 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18199815" @default.
• W1969823770 hasPublicationYear "2008" @default.
• W1969823770 type Work @default.
• W1969823770 sameAs 1969823770 @default.
• W1969823770 citedByCount "50" @default.
• W1969823770 countsByYear W19698237702012 @default.
• W1969823770 countsByYear W19698237702013 @default.
• W1969823770 countsByYear W19698237702014 @default.
• W1969823770 countsByYear W19698237702015 @default.
• W1969823770 countsByYear W19698237702016 @default.
• W1969823770 countsByYear W19698237702017 @default.
• W1969823770 countsByYear W19698237702018 @default.
• W1969823770 countsByYear W19698237702019 @default.
• W1969823770 countsByYear W19698237702020 @default.
• W1969823770 countsByYear W19698237702021 @default.
• W1969823770 countsByYear W19698237702022 @default.
• W1969823770 countsByYear W19698237702023 @default.
• W1969823770 crossrefType "journal-article" @default.
• W1969823770 hasAuthorship W1969823770A5003823818 @default.
• W1969823770 hasAuthorship W1969823770A5078925464 @default.
• W1969823770 hasConcept C112592302 @default.

• next