FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969825208> ?p ?o ?g. }

• W1969825208 endingPage "995" @default.
• W1969825208 startingPage "995" @default.
• W1969825208 abstract "The exposure of various human populations to Cd2+ is of increasing health concern. After its gastrointestinal absorption into the bloodstream, Cd2+ binds to α2-macroglobulin and serum albumin. Although animal studies have demonstrated that meso-2,3-dimercaptosuccinic acid (DMSA) and diethylenetriamine pentaacetic acid (DTPA) can effectively mobilize Cd2+ to urine and decrease the Cd concentrations of the kidneys, the liver and the brain, not much is known about the abstraction of Cd2+ from blood plasma proteins. We prepared a stock of Cd2+ spiked rabbit plasma (2.0 μg of Cd2+/mL) and analyzed aliquots by size exclusion chromatography coupled on-line to an inductively coupled plasma atomic emission spectrometer (SEC-ICP-AES) while simultaneously monitoring the emission lines of Ca, Cd, Cu, Fe, and Zn. After the addition of 0.33 mM, 0.66 mM or 0.99 mM of DMSA, DTPA, 2,3-dimercapto-1-propanesulfonic acid (DMPS) or N-acetyl-l-cysteine (NAC) to plasma aliquots, the obtained mixtures were analyzed by SEC-ICP-AES after 5 min and 30 min. None of the investigated compounds adversely affected the plasma distribution of Fe at all investigated doses. At 0.33 mM, DTPA was most effective at mobilizing plasma protein bound Cd2+ to a ∼5 kDa Cd-species (100% removal), followed by DMPS (94%), DMSA (83%) and NAC (3%). All investigated compounds also mobilized Zn2+ from plasma proteins to ∼5 kDa Zn-species (DTPA: 80% removal; DMPS: 63%; DMSA: 29% and NAC: 3%). The addition of DTPA resulted in the dose-dependent elution of a [Ca–DTPA]3− complex. Based on these results, 0.33 mM DMSA represents the best compromise that can be achieved between maximizing the abstraction of Cd2+ from plasma proteins (83%), while minimizing the mobilization of Zn2+ from plasma proteins (29%), and avoiding the complexation of Ca2+." @default.
• W1969825208 created "2016-06-24" @default.
• W1969825208 creator A5084203789 @default.
• W1969825208 creator A5085594354 @default.
• W1969825208 date "2012-01-01" @default.
• W1969825208 modified "2023-09-27" @default.
• W1969825208 title "In vitro assessment of chelating agents with regard to their abstraction efficiency of Cd2+ bound to plasma proteins" @default.
• W1969825208 cites W1498394482 @default.
• W1969825208 cites W1964641434 @default.
• W1969825208 cites W1965065988 @default.
• W1969825208 cites W1970658270 @default.
• W1969825208 cites W1975838952 @default.
• W1969825208 cites W1976055216 @default.
• W1969825208 cites W1983127813 @default.
• W1969825208 cites W1984902120 @default.
• W1969825208 cites W1985861484 @default.
• W1969825208 cites W1993623325 @default.
• W1969825208 cites W2006342727 @default.
• W1969825208 cites W2017578362 @default.
• W1969825208 cites W2017969179 @default.
• W1969825208 cites W2019612771 @default.
• W1969825208 cites W2025865267 @default.
• W1969825208 cites W2033285747 @default.
• W1969825208 cites W2033968745 @default.
• W1969825208 cites W2043020476 @default.
• W1969825208 cites W2052335753 @default.
• W1969825208 cites W2057341791 @default.
• W1969825208 cites W2058240342 @default.
• W1969825208 cites W2058402591 @default.
• W1969825208 cites W2063575064 @default.
• W1969825208 cites W2072080603 @default.
• W1969825208 cites W2074691190 @default.
• W1969825208 cites W2075840370 @default.
• W1969825208 cites W2076401873 @default.
• W1969825208 cites W2077065305 @default.
• W1969825208 cites W2083382935 @default.
• W1969825208 cites W2083589874 @default.
• W1969825208 cites W2089741236 @default.
• W1969825208 cites W2092090776 @default.
• W1969825208 cites W2094988587 @default.
• W1969825208 cites W2101813430 @default.
• W1969825208 cites W2103474203 @default.
• W1969825208 cites W2105456127 @default.
• W1969825208 cites W2107089247 @default.
• W1969825208 cites W2113491662 @default.
• W1969825208 cites W2117849094 @default.
• W1969825208 cites W2118564232 @default.
• W1969825208 cites W2123855629 @default.
• W1969825208 cites W2127481813 @default.
• W1969825208 cites W2127895812 @default.
• W1969825208 cites W2128037026 @default.
• W1969825208 cites W2141043744 @default.
• W1969825208 cites W2145892496 @default.
• W1969825208 cites W2148623861 @default.
• W1969825208 cites W2150649413 @default.
• W1969825208 cites W2170448114 @default.
• W1969825208 cites W2266355581 @default.
• W1969825208 cites W2314090418 @default.
• W1969825208 cites W2419692261 @default.
• W1969825208 cites W2949985930 @default.
• W1969825208 cites W4237033104 @default.
• W1969825208 cites W4361868636 @default.
• W1969825208 doi "https://doi.org/10.1039/c2mt20084h" @default.
• W1969825208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22820874" @default.
• W1969825208 hasPublicationYear "2012" @default.
• W1969825208 type Work @default.
• W1969825208 sameAs 1969825208 @default.
• W1969825208 citedByCount "7" @default.
• W1969825208 countsByYear W19698252082013 @default.
• W1969825208 countsByYear W19698252082014 @default.
• W1969825208 countsByYear W19698252082017 @default.
• W1969825208 countsByYear W19698252082020 @default.
• W1969825208 crossrefType "journal-article" @default.
• W1969825208 hasAuthorship W1969825208A5084203789 @default.
• W1969825208 hasAuthorship W1969825208A5085594354 @default.
• W1969825208 hasBestOaLocation W19698252081 @default.
• W1969825208 hasConcept C121332964 @default.
• W1969825208 hasConcept C13965031 @default.
• W1969825208 hasConcept C146543888 @default.
• W1969825208 hasConcept C179104552 @default.
• W1969825208 hasConcept C181199279 @default.
• W1969825208 hasConcept C185592680 @default.
• W1969825208 hasConcept C193363816 @default.
• W1969825208 hasConcept C197404232 @default.
• W1969825208 hasConcept C202751555 @default.
• W1969825208 hasConcept C2776125364 @default.
• W1969825208 hasConcept C2779201268 @default.
• W1969825208 hasConcept C33619061 @default.
• W1969825208 hasConcept C43617362 @default.
• W1969825208 hasConcept C55493867 @default.
• W1969825208 hasConcept C62520636 @default.
• W1969825208 hasConcept C82706917 @default.
• W1969825208 hasConcept C95974651 @default.
• W1969825208 hasConceptScore W1969825208C121332964 @default.
• W1969825208 hasConceptScore W1969825208C13965031 @default.
• W1969825208 hasConceptScore W1969825208C146543888 @default.
• W1969825208 hasConceptScore W1969825208C179104552 @default.
• W1969825208 hasConceptScore W1969825208C181199279 @default.

• next