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• W1969826615 abstract "Two suspect aneugens (hydroquinone and econazole nitrate) were examined for their ability to induce micronuclei in a number of V79 Chinese hamster cell lines which express rat cytochrome P-450 cDNAs. Hydroquinone elevated micronucleated cell frequencies in a dose-dependent manner in cell lines V79, XEM2 (expresses CYP1A1) and SD1 (expresses CYP2B1). Econazole nitrate was an effective inducer of micronuclei over a narrow dose range in cell lines V79, XEM2 and XEMd-MZ (expresses CYP1A2). The different cell lines showed similar responses to the test agents, indicating that hydroquinone is not a substrate for biotransformation by rat CYP1A1 or CYP2B1, nor is econazole nitrate biotransformed by rat CYP1A1 or CYP1A2." @default.
• W1969826615 created "2016-06-24" @default.
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• W1969826615 creator A5084653587 @default.
• W1969826615 date "1993-05-01" @default.
• W1969826615 modified "2023-10-01" @default.
• W1969826615 title "Induction of micronuclei in V79 Chinese hamster cells by hydroquinone and econazole nitrate" @default.
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• W1969826615 doi "https://doi.org/10.1016/0027-5107(93)90147-8" @default.
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