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- W1969831566 abstract "Letters and Corrections15 September 1989Wider Inclusion Criteria Needed for Thrombolytic TherapyRichard Peto, MA, MSc, Rory Collins, MBBS, Peter Sleight, MD, DMRichard Peto, MA, MScSearch for more papers by this author, Rory Collins, MBBSSearch for more papers by this author, Peter Sleight, MD, DMSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-111-6-540_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:The article by Lee and colleagues (1) and the accompanying editorial by Tate and Dehmer (2) on the smallness of the proportion of patients eligible for thrombolytic therapy makes it clear that in deciding who should be offered thrombolytics many U.S. physicians may simply adopt the restrictive eligibility criteria of those trials (3-5) that excluded older patients, treated only those presenting within a few hours of symptom onset, and required definite electrocardiographic (ECG) evidence of infarction. Such restrictive-entry trials cannot, however, provide direct evidence as to whether their restrictions were appropriate—that is, they obviously cannot assess directly...References1. LeeWeisbergBrandRouanGoldman TMDGL. Candidates for thrombolysis among emergency room patients with acute chest pain. Ann Intern Med. 1989;110:957-62. LinkGoogle Scholar2. TateDehmer DG. New challenges for thrombolytic therapy. Ann Intern Med. 1989;110:953-5. LinkGoogle Scholar3. TopolCaliffKereiakesGeorge ERDB. Thrombolysis and Angioplasty in Myocardial Infarction (TAMI) trial. J Am Coll Cardiol. 1987;10:65B-74B. CrossrefMedlineGoogle Scholar4. PassamaniHodgesHerman EMM. The Thrombolysis in Myocardial Infarction (TIMI) phase II pilot study: tissue plasminogen activator followed by percutaneous transluminal coronary angioplasty. J Am Coll Cardiol. 1987;10:51B-64B. CrossrefMedlineGoogle Scholar5. KennedyMartinDavis JGK. The Western Washington Intravenous Streptokinase in Acute Myocardial Infarction Randomized Trial. Circulation. 1988;77:345-52. CrossrefMedlineGoogle Scholar6. . Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17 187 cases of suspected acute myocardial infarction: ISIS-2. Lancet. 1988;2:349-60. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: ISIS Trial Office Radcliffe Infirmary Oxford United Kingdom PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByEligibility for intravenous thrombolysis in suspected acute myocardial infarction.Optimizing thrombolytic therapy of acute myocardial infarction. 15 September 1989Volume 111, Issue 6Page: 540-540KeywordsElectrocardiographyInfarction Issue Published: 15 September 1989 PDF DownloadLoading ..." @default.
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- W1969831566 title "Wider Inclusion Criteria Needed for Thrombolytic Therapy" @default.
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