FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969845038> ?p ?o ?g. }

• W1969845038 endingPage "1557" @default.
• W1969845038 startingPage "1547" @default.
• W1969845038 abstract "Adenovirus vectors based on human serotype 5 can induce potent CD8 T cell responses to vector-encoded transgenic antigens. However, the individual contribution of different cell types expressing antigen upon adenovirus vector injection to the generation of antigen-directed adaptive immune responses is poorly understood so far. We investigated the role of hepatocytes, skeletal muscle, and hematopoietic cells for the induction of cellular and humoral immune responses by miRNA-mediated tissue-specific silencing of antigen expression. Using hepatitis B small surface antigen (HBsAg) as the vector-encoded transgene we show that adenovirus vector dissemination from an intramuscular (i.m.) injection site into the liver followed by HBsAg expression in hepatocytes can limit early priming of CD8 T cells and the generation of anti-HBsAg antibody responses. However, hepatocyte-specific miRNA122a-mediated silencing of HBsAg expression overcame these limitations. Early clonal expansion of K(b)/S(190-197)-specific CD8 T cells was significantly enhanced and improved polyfunctionality of CD8 T cells was found. Furthermore, miRNA122a-mediated antigen silencing induced significantly higher anti-HBsAg antibody titers allowing an up to 100-fold vector dose reduction. These results indicate that miRNA-mediated regulation of antigen expression in the context of adenovirus vectors can significantly improve transgene product-directed immune responses. This finding could be of interest for future adenovirus vaccine vector development." @default.
• W1969845038 created "2016-06-24" @default.
• W1969845038 creator A5028547118 @default.
• W1969845038 creator A5044058894 @default.
• W1969845038 creator A5050314365 @default.
• W1969845038 creator A5062166986 @default.
• W1969845038 creator A5063055218 @default.
• W1969845038 creator A5072195169 @default.
• W1969845038 date "2011-08-01" @default.
• W1969845038 modified "2023-09-27" @default.
• W1969845038 title "miRNA-mediated Silencing in Hepatocytes Can Increase Adaptive Immune Responses to Adenovirus Vector-delivered Transgenic Antigens" @default.
• W1969845038 cites W1499355728 @default.
• W1969845038 cites W1512802465 @default.
• W1969845038 cites W1922233425 @default.
• W1969845038 cites W1942870285 @default.
• W1969845038 cites W1971744004 @default.
• W1969845038 cites W1977020173 @default.
• W1969845038 cites W1980890790 @default.
• W1969845038 cites W1982787126 @default.
• W1969845038 cites W1982805293 @default.
• W1969845038 cites W1988849266 @default.
• W1969845038 cites W1993408035 @default.
• W1969845038 cites W1996235312 @default.
• W1969845038 cites W2012714016 @default.
• W1969845038 cites W2014063093 @default.
• W1969845038 cites W2016071978 @default.
• W1969845038 cites W2023545075 @default.
• W1969845038 cites W2024397909 @default.
• W1969845038 cites W2030404196 @default.
• W1969845038 cites W2030699641 @default.
• W1969845038 cites W2044474105 @default.
• W1969845038 cites W2046471199 @default.
• W1969845038 cites W2051758487 @default.
• W1969845038 cites W2054258731 @default.
• W1969845038 cites W2057893105 @default.
• W1969845038 cites W2059382687 @default.
• W1969845038 cites W2070294322 @default.
• W1969845038 cites W2071710058 @default.
• W1969845038 cites W2073739917 @default.
• W1969845038 cites W2075909997 @default.
• W1969845038 cites W2087712295 @default.
• W1969845038 cites W2090851055 @default.
• W1969845038 cites W2097646387 @default.
• W1969845038 cites W2109394975 @default.
• W1969845038 cites W2112383089 @default.
• W1969845038 cites W2116071714 @default.
• W1969845038 cites W2119354849 @default.
• W1969845038 cites W2121809112 @default.
• W1969845038 cites W2132764515 @default.
• W1969845038 cites W2140243174 @default.
• W1969845038 cites W2144009005 @default.
• W1969845038 cites W2146046635 @default.
• W1969845038 cites W2146527206 @default.
• W1969845038 cites W2159453092 @default.
• W1969845038 cites W2163787552 @default.
• W1969845038 cites W2167762480 @default.
• W1969845038 cites W2168458927 @default.
• W1969845038 cites W2170874107 @default.
• W1969845038 cites W2171985637 @default.
• W1969845038 cites W2176798835 @default.
• W1969845038 cites W2332645155 @default.
• W1969845038 doi "https://doi.org/10.1038/mt.2011.83" @default.
• W1969845038 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3149177" @default.
• W1969845038 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21556053" @default.
• W1969845038 hasPublicationYear "2011" @default.
• W1969845038 type Work @default.
• W1969845038 sameAs 1969845038 @default.
• W1969845038 citedByCount "7" @default.
• W1969845038 countsByYear W19698450382012 @default.
• W1969845038 countsByYear W19698450382014 @default.
• W1969845038 countsByYear W19698450382016 @default.
• W1969845038 countsByYear W19698450382017 @default.
• W1969845038 countsByYear W19698450382022 @default.
• W1969845038 crossrefType "journal-article" @default.
• W1969845038 hasAuthorship W1969845038A5028547118 @default.
• W1969845038 hasAuthorship W1969845038A5044058894 @default.
• W1969845038 hasAuthorship W1969845038A5050314365 @default.
• W1969845038 hasAuthorship W1969845038A5062166986 @default.
• W1969845038 hasAuthorship W1969845038A5063055218 @default.
• W1969845038 hasAuthorship W1969845038A5072195169 @default.
• W1969845038 hasBestOaLocation W19698450381 @default.
• W1969845038 hasConcept C102230213 @default.
• W1969845038 hasConcept C104317684 @default.
• W1969845038 hasConcept C119056186 @default.
• W1969845038 hasConcept C147483822 @default.
• W1969845038 hasConcept C154317977 @default.
• W1969845038 hasConcept C159047783 @default.
• W1969845038 hasConcept C167672396 @default.
• W1969845038 hasConcept C202751555 @default.
• W1969845038 hasConcept C203014093 @default.
• W1969845038 hasConcept C2522874641 @default.
• W1969845038 hasConcept C2777410769 @default.
• W1969845038 hasConcept C2780593183 @default.
• W1969845038 hasConcept C32470452 @default.
• W1969845038 hasConcept C40767141 @default.
• W1969845038 hasConcept C55493867 @default.
• W1969845038 hasConcept C86803240 @default.
• W1969845038 hasConcept C8891405 @default.

• next