Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969848259> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W1969848259 endingPage "97" @default.
- W1969848259 startingPage "89" @default.
- W1969848259 abstract "A 24-week, double-blind, multi-center, randomised parallel group study compared the efficacy and safety of 800 mg bid cyclandelate with placebo in patients with mild to moderate dementia of primary degenerative or vascular origin. A total of 196 patients entered the study, 147 patients completed treatment in adherence with the protocol. Primary outcome measures were the cognitive score of the Alzheimer's Disease Assessment Scale (ADAS-Cog), the subscale Instrumental Activities of Daily Living of the Nurses' Observation Scale for Geriatric Patients (NOSGER-IADL) and the Clinical Global Impressions of Change (CGI-C). Safety assessments included adverse events, vital signs, ECG and clinical laboratory parameters. The primary efficacy results based on a multi-level responder analysis including ADAS-Cog, NOSGER-IADL and CGI-C failed to demonstrate statistical superiority of cyclandelate in comparison to placebo. The direction of changes favored cyclandelate in each of the variables, but the differences to placebo were small and varied considerably between patients and centers. Retrospective exploratory analyses suggested that efficacy of cyclandelate might be dependent on the severity of the disease. The treatment effects in favor of cyclandelate were statistically significant in the subgroup of moderately impaired patients (MMSE at baseline <18) for ADAS-Cog (delta = -4.0 points, p = 0.015) and CGI-C (delta = -0.4 points, p = 0.043) but not for NOSGER-IADL (delta = -1.6 points, p = 0.059). When patients were stepwise selected for the severity of the disease according to ADAS-Cog at baseline (>15, >20, >25 points), statistical significance was reached for ADAS-Cog and NOSGER-IADL beginning with the step ADAS-Cog >20 points: delta ADAS-Cog = -3.9 points, p = 0.044; delta NOSGER-IADL = -1.0, p = 0.023. The treatment differences increased further with the step ADAS-Cog >25 points: delta ADAS-Cog = -7.0 points, p = 0.008; delta NOSGER-IADL = -1.7, p = 0.003. Treatment differences in CGI-C increased marginally with the stepwise selection but did not reach statistical significance. The drug was safe and well tolerated." @default.
- W1969848259 created "2016-06-24" @default.
- W1969848259 creator A5063552326 @default.
- W1969848259 creator A5067238265 @default.
- W1969848259 creator A5074762315 @default.
- W1969848259 creator A5077225535 @default.
- W1969848259 creator A5054112379 @default.
- W1969848259 date "2000-05-01" @default.
- W1969848259 modified "2023-10-04" @default.
- W1969848259 title "Cyclandelate in the Treatment of Patients with Mild to Moderate Primary Degenerative Dementia of the Alzheimer Type or Vascular Dementia: Experience from a Placebo Controlled Multi-center Study" @default.
- W1969848259 doi "https://doi.org/10.1055/s-2000-7978" @default.
- W1969848259 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10855459" @default.
- W1969848259 hasPublicationYear "2000" @default.
- W1969848259 type Work @default.
- W1969848259 sameAs 1969848259 @default.
- W1969848259 citedByCount "8" @default.
- W1969848259 countsByYear W19698482592013 @default.
- W1969848259 countsByYear W19698482592022 @default.
- W1969848259 crossrefType "journal-article" @default.
- W1969848259 hasAuthorship W1969848259A5054112379 @default.
- W1969848259 hasAuthorship W1969848259A5063552326 @default.
- W1969848259 hasAuthorship W1969848259A5067238265 @default.
- W1969848259 hasAuthorship W1969848259A5074762315 @default.
- W1969848259 hasAuthorship W1969848259A5077225535 @default.
- W1969848259 hasConcept C126322002 @default.
- W1969848259 hasConcept C141071460 @default.
- W1969848259 hasConcept C142724271 @default.
- W1969848259 hasConcept C1862650 @default.
- W1969848259 hasConcept C197934379 @default.
- W1969848259 hasConcept C204787440 @default.
- W1969848259 hasConcept C27081682 @default.
- W1969848259 hasConcept C2776890885 @default.
- W1969848259 hasConcept C2777952318 @default.
- W1969848259 hasConcept C2779134260 @default.
- W1969848259 hasConcept C2779483572 @default.
- W1969848259 hasConcept C502032728 @default.
- W1969848259 hasConcept C535046627 @default.
- W1969848259 hasConcept C65409693 @default.
- W1969848259 hasConcept C71924100 @default.
- W1969848259 hasConcept C79544238 @default.
- W1969848259 hasConceptScore W1969848259C126322002 @default.
- W1969848259 hasConceptScore W1969848259C141071460 @default.
- W1969848259 hasConceptScore W1969848259C142724271 @default.
- W1969848259 hasConceptScore W1969848259C1862650 @default.
- W1969848259 hasConceptScore W1969848259C197934379 @default.
- W1969848259 hasConceptScore W1969848259C204787440 @default.
- W1969848259 hasConceptScore W1969848259C27081682 @default.
- W1969848259 hasConceptScore W1969848259C2776890885 @default.
- W1969848259 hasConceptScore W1969848259C2777952318 @default.
- W1969848259 hasConceptScore W1969848259C2779134260 @default.
- W1969848259 hasConceptScore W1969848259C2779483572 @default.
- W1969848259 hasConceptScore W1969848259C502032728 @default.
- W1969848259 hasConceptScore W1969848259C535046627 @default.
- W1969848259 hasConceptScore W1969848259C65409693 @default.
- W1969848259 hasConceptScore W1969848259C71924100 @default.
- W1969848259 hasConceptScore W1969848259C79544238 @default.
- W1969848259 hasIssue "3" @default.
- W1969848259 hasLocation W19698482591 @default.
- W1969848259 hasLocation W19698482592 @default.
- W1969848259 hasOpenAccess W1969848259 @default.
- W1969848259 hasPrimaryLocation W19698482591 @default.
- W1969848259 hasRelatedWork W1990948493 @default.
- W1969848259 hasRelatedWork W2021579004 @default.
- W1969848259 hasRelatedWork W2027040649 @default.
- W1969848259 hasRelatedWork W2064879719 @default.
- W1969848259 hasRelatedWork W2069814229 @default.
- W1969848259 hasRelatedWork W2078280064 @default.
- W1969848259 hasRelatedWork W2085830368 @default.
- W1969848259 hasRelatedWork W2104130066 @default.
- W1969848259 hasRelatedWork W313460363 @default.
- W1969848259 hasRelatedWork W2470527971 @default.
- W1969848259 hasVolume "33" @default.
- W1969848259 isParatext "false" @default.
- W1969848259 isRetracted "false" @default.
- W1969848259 magId "1969848259" @default.
- W1969848259 workType "article" @default.