Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969848449> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W1969848449 abstract "To study the possible role of alpha-2 receptors in intractable asthmatics, we investigated the ameliorative effects of 2-[2-(4,5-dihydro-1H-imidazol-2-yl)-1-phenylthyl]pyridine dihydrochloride sesquihydrate (DG-5128) on 10 steroid-dependent asthmatic patients. The forced expiratory volume in 1 second (FEV1) and the respiratory resistance (Rrs) were measured 1, 2, and 3 hours after oral administration of 200 mg DG-5128 and compared with the premedication measurements. Two hours after DG-5128 administration, the FEV1 rose significantly (p less than 0.01) and the Rrs decreased significantly (p less than 0.05). Asthmatic symptoms (cough, wheezing, dyspnea) also improved in 80% of the patients. This finding raises the possibility that alpha-2 adrenoceptors exist in human airways, that they play an important role in the pathophysiology of asthma, and that the overfunction of these alpha-2 adrenoceptors and/or Gi-protein cause intractable asthma." @default.
- W1969848449 created "2016-06-24" @default.
- W1969848449 creator A5060015303 @default.
- W1969848449 creator A5062513710 @default.
- W1969848449 creator A5072388564 @default.
- W1969848449 date "1988-01-01" @default.
- W1969848449 modified "2023-09-24" @default.
- W1969848449 title "Inhibitory Effect of DG-5128 on Steroid-Dependent Asthma" @default.
- W1969848449 cites W1496654715 @default.
- W1969848449 cites W1562393866 @default.
- W1969848449 cites W1623654581 @default.
- W1969848449 cites W1978274173 @default.
- W1969848449 cites W1990188075 @default.
- W1969848449 cites W2039264494 @default.
- W1969848449 cites W2041769124 @default.
- W1969848449 cites W2051018863 @default.
- W1969848449 doi "https://doi.org/10.3109/02770908809071373" @default.
- W1969848449 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2906933" @default.
- W1969848449 hasPublicationYear "1988" @default.
- W1969848449 type Work @default.
- W1969848449 sameAs 1969848449 @default.
- W1969848449 citedByCount "4" @default.
- W1969848449 countsByYear W19698484492021 @default.
- W1969848449 crossrefType "journal-article" @default.
- W1969848449 hasAuthorship W1969848449A5060015303 @default.
- W1969848449 hasAuthorship W1969848449A5062513710 @default.
- W1969848449 hasAuthorship W1969848449A5072388564 @default.
- W1969848449 hasConcept C10162356 @default.
- W1969848449 hasConcept C126322002 @default.
- W1969848449 hasConcept C134018914 @default.
- W1969848449 hasConcept C2776042228 @default.
- W1969848449 hasConcept C2776178081 @default.
- W1969848449 hasConcept C2777714996 @default.
- W1969848449 hasConcept C2778300832 @default.
- W1969848449 hasConcept C42219234 @default.
- W1969848449 hasConcept C534529494 @default.
- W1969848449 hasConcept C71924100 @default.
- W1969848449 hasConceptScore W1969848449C10162356 @default.
- W1969848449 hasConceptScore W1969848449C126322002 @default.
- W1969848449 hasConceptScore W1969848449C134018914 @default.
- W1969848449 hasConceptScore W1969848449C2776042228 @default.
- W1969848449 hasConceptScore W1969848449C2776178081 @default.
- W1969848449 hasConceptScore W1969848449C2777714996 @default.
- W1969848449 hasConceptScore W1969848449C2778300832 @default.
- W1969848449 hasConceptScore W1969848449C42219234 @default.
- W1969848449 hasConceptScore W1969848449C534529494 @default.
- W1969848449 hasConceptScore W1969848449C71924100 @default.
- W1969848449 hasLocation W19698484491 @default.
- W1969848449 hasLocation W19698484492 @default.
- W1969848449 hasOpenAccess W1969848449 @default.
- W1969848449 hasPrimaryLocation W19698484491 @default.
- W1969848449 hasRelatedWork W113205919 @default.
- W1969848449 hasRelatedWork W1981726547 @default.
- W1969848449 hasRelatedWork W2025567563 @default.
- W1969848449 hasRelatedWork W2048822030 @default.
- W1969848449 hasRelatedWork W2077930116 @default.
- W1969848449 hasRelatedWork W2121034908 @default.
- W1969848449 hasRelatedWork W2377079861 @default.
- W1969848449 hasRelatedWork W2596924838 @default.
- W1969848449 hasRelatedWork W3140877575 @default.
- W1969848449 hasRelatedWork W629585419 @default.
- W1969848449 isParatext "false" @default.
- W1969848449 isRetracted "false" @default.
- W1969848449 magId "1969848449" @default.
- W1969848449 workType "article" @default.