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- W1969849138 abstract "Aminophosphines 2-(diphenylphosphino)-1-methylimidazole (dpim) and diphenyl-2-pyridylphosphine (PPh2py) have been used to prepare two series of Ru(II) arene complexes of formulae [(η6-p-cymene)Ru(κ2-O,O′-X)(κ1-P-dpim)]Y (series a: 1a·Y–3a·Y) and [(η6-p-cymene)Ru(κ2-O,O′-X)(κ1-P-PPh2py)]Y (series b: 1b·Y–3b·Y) (where X = acac, acetylacetonate; bzac, benzoyl acetonate; dbzm, dibenzoyl methanoate; Y = BF4, BPh4). The structures of 1a·BF4, 1a·BPh4, 3a·BF4, 1b·BPh4 and 3b·BPh4 were determined by X-ray diffraction. The tetrafluoroborate derivatives are more soluble in organic solvents than their tetraphenylborate counterparts. Five BF4− derivatives (all except the unstable 1b·BF4) were selected to evaluate the cytotoxic behavior in vitro against the human cancer cell lines MCF-7 (breast cancer) and CAPAN-1 (pancreatic cancer). 2b·BF4 and 3b·BF4 exhibited IC50 values similar to those of cisplatin. Electrophoresis and AFM studies showed good correspondence between the biological activity levels of 2b·BF4 and 3b·BF4 and their ability to modify the DNA structure. Hydrolytic studies indicate that aquation could be involved in the activation mechanism of these complexes and confirm that the hydrolysis rate of 3b·BF4 is higher than that of 3a·BF4. Thus, the cytotoxic activity trends are explained in terms of the higher reactivity of derivatives from series b, which in turn is rationalized as being the result of the electronic features of dpim and PPh2py established by cyclic voltammetry measurements." @default.
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- W1969849138 date "2012-12-01" @default.
- W1969849138 modified "2023-10-18" @default.
- W1969849138 title "Preparation of new half sandwich ruthenium arene complexes with aminophosphines as potential chemotherapeutics" @default.
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- W1969849138 cites W1966182479 @default.
- W1969849138 cites W1967519684 @default.
- W1969849138 cites W1967908054 @default.
- W1969849138 cites W1969972637 @default.
- W1969849138 cites W1971380388 @default.
- W1969849138 cites W1971967721 @default.
- W1969849138 cites W1981603699 @default.
- W1969849138 cites W1989692639 @default.
- W1969849138 cites W1990886938 @default.
- W1969849138 cites W1993051678 @default.
- W1969849138 cites W1993398839 @default.
- W1969849138 cites W1996273492 @default.
- W1969849138 cites W1998722626 @default.
- W1969849138 cites W2002015225 @default.
- W1969849138 cites W2003737094 @default.
- W1969849138 cites W2004933732 @default.
- W1969849138 cites W2012338094 @default.
- W1969849138 cites W2014731464 @default.
- W1969849138 cites W2017346763 @default.
- W1969849138 cites W2023271753 @default.
- W1969849138 cites W2025087215 @default.
- W1969849138 cites W2027840734 @default.
- W1969849138 cites W2028103648 @default.
- W1969849138 cites W2029852148 @default.
- W1969849138 cites W2033990154 @default.
- W1969849138 cites W2034947652 @default.
- W1969849138 cites W2036668937 @default.
- W1969849138 cites W2039559098 @default.
- W1969849138 cites W2039597106 @default.
- W1969849138 cites W2040055476 @default.
- W1969849138 cites W2042581629 @default.
- W1969849138 cites W2043412876 @default.
- W1969849138 cites W2050077837 @default.
- W1969849138 cites W2050894450 @default.
- W1969849138 cites W2051361308 @default.
- W1969849138 cites W2051441149 @default.
- W1969849138 cites W2052136566 @default.
- W1969849138 cites W2053726603 @default.
- W1969849138 cites W2054890225 @default.
- W1969849138 cites W2055938192 @default.
- W1969849138 cites W2058848030 @default.
- W1969849138 cites W2059209248 @default.
- W1969849138 cites W2064706515 @default.
- W1969849138 cites W2068633288 @default.
- W1969849138 cites W2069286027 @default.
- W1969849138 cites W2069305922 @default.
- W1969849138 cites W2071772915 @default.
- W1969849138 cites W2073037830 @default.
- W1969849138 cites W2075346893 @default.
- W1969849138 cites W2081648448 @default.
- W1969849138 cites W2084171085 @default.
- W1969849138 cites W2086627300 @default.
- W1969849138 cites W2087459002 @default.
- W1969849138 cites W2087963964 @default.
- W1969849138 cites W2094642658 @default.
- W1969849138 cites W2103459003 @default.
- W1969849138 cites W2112891180 @default.
- W1969849138 cites W2113701650 @default.
- W1969849138 cites W2116966532 @default.
- W1969849138 cites W2126695283 @default.
- W1969849138 cites W2129213133 @default.
- W1969849138 cites W2130728974 @default.
- W1969849138 cites W2143981217 @default.
- W1969849138 cites W2147304506 @default.
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- W1969849138 cites W2171730439 @default.
- W1969849138 cites W2317725423 @default.
- W1969849138 cites W2330604698 @default.
- W1969849138 doi "https://doi.org/10.1016/j.jinorgbio.2012.07.022" @default.
- W1969849138 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23085598" @default.
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