FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969858462> ?p ?o ?g. }

• W1969858462 endingPage "1110" @default.
• W1969858462 startingPage "1104" @default.
• W1969858462 abstract "HER2 is a promising target for immunotherapeutic interventions with T cell-based approaches since it is amplified and overexpressed in 20–30% of breast cancers. However, several previous studies including ours showed that HER2-overexpressing tumors may escape cytotoxic T lymphocyte-mediated lysis by downregulating MHC Class I and components of the antigen-processing machinery. The aims of the present study were to analyze the relationship between HER2 and MHC Class I expression and to elucidate the mechanisms underlying MHC Class I downregulation in breast cancer. We explored expression of HER2, MHC Class I, PTEN, Ki67, estrogen and progesterone expression in 70 breast cancer patients by immunohistochemistry (IHC) and analyzed their correlation. We also explored the components of the signal transduction pathway that are involved in the regulation of MHC Class I expression using small-interfering RNAs targeting HER2 as well as an inhibitor of HER2 signaling. HER2 expression in breast cancers correlated inversely with MHC Class I expression analyzed by IHC. HER2 depletion by small-interfering RNAs resulted in MHC Class I upregulation. Moreover, MHC Class I expression on breast cancer cell lines was upregulated by PD98059, an inhibitor of mitogen-associated protein kinases, in a dose-dependent manner. Thus, agents that target the MAPK signaling pathway may increase MHC Class I expression in breast cancer cells." @default.
• W1969858462 created "2016-06-24" @default.
• W1969858462 creator A5001199044 @default.
• W1969858462 creator A5007763021 @default.
• W1969858462 creator A5012585624 @default.
• W1969858462 creator A5013219387 @default.
• W1969858462 creator A5028287372 @default.
• W1969858462 creator A5031604448 @default.
• W1969858462 creator A5036824051 @default.
• W1969858462 creator A5043253617 @default.
• W1969858462 creator A5052339023 @default.
• W1969858462 creator A5053914726 @default.
• W1969858462 creator A5069279463 @default.
• W1969858462 creator A5079163477 @default.
• W1969858462 creator A5081825821 @default.
• W1969858462 creator A5090779125 @default.
• W1969858462 creator A5091098368 @default.
• W1969858462 creator A5091296972 @default.
• W1969858462 date "2012-10-01" @default.
• W1969858462 modified "2023-10-17" @default.
• W1969858462 title "Expression of MHC Class I on breast cancer cells correlates inversely with HER2 expression" @default.
• W1969858462 cites W1580971414 @default.
• W1969858462 cites W1982507863 @default.
• W1969858462 cites W1991228426 @default.
• W1969858462 cites W1997006452 @default.
• W1969858462 cites W2007275707 @default.
• W1969858462 cites W2015562061 @default.
• W1969858462 cites W2017063086 @default.
• W1969858462 cites W2024223018 @default.
• W1969858462 cites W2058070604 @default.
• W1969858462 cites W2058864999 @default.
• W1969858462 cites W2059356113 @default.
• W1969858462 cites W2059395045 @default.
• W1969858462 cites W2059411043 @default.
• W1969858462 cites W2064974685 @default.
• W1969858462 cites W2077580829 @default.
• W1969858462 cites W2088819465 @default.
• W1969858462 cites W2097988373 @default.
• W1969858462 cites W2099954087 @default.
• W1969858462 cites W2101030466 @default.
• W1969858462 cites W2107311126 @default.
• W1969858462 cites W2110250476 @default.
• W1969858462 cites W2121198752 @default.
• W1969858462 cites W2127057139 @default.
• W1969858462 cites W2130893874 @default.
• W1969858462 cites W2131361386 @default.
• W1969858462 cites W2140747721 @default.
• W1969858462 cites W2145136557 @default.
• W1969858462 cites W2158852351 @default.
• W1969858462 cites W2159363679 @default.
• W1969858462 cites W4232529261 @default.
• W1969858462 cites W4361867966 @default.
• W1969858462 doi "https://doi.org/10.4161/onci.21056" @default.
• W1969858462 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3494624" @default.
• W1969858462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23170258" @default.
• W1969858462 hasPublicationYear "2012" @default.
• W1969858462 type Work @default.
• W1969858462 sameAs 1969858462 @default.
• W1969858462 citedByCount "60" @default.
• W1969858462 countsByYear W19698584622013 @default.
• W1969858462 countsByYear W19698584622014 @default.
• W1969858462 countsByYear W19698584622015 @default.
• W1969858462 countsByYear W19698584622016 @default.
• W1969858462 countsByYear W19698584622017 @default.
• W1969858462 countsByYear W19698584622018 @default.
• W1969858462 countsByYear W19698584622019 @default.
• W1969858462 countsByYear W19698584622020 @default.
• W1969858462 countsByYear W19698584622021 @default.
• W1969858462 countsByYear W19698584622022 @default.
• W1969858462 countsByYear W19698584622023 @default.
• W1969858462 crossrefType "journal-article" @default.
• W1969858462 hasAuthorship W1969858462A5001199044 @default.
• W1969858462 hasAuthorship W1969858462A5007763021 @default.
• W1969858462 hasAuthorship W1969858462A5012585624 @default.
• W1969858462 hasAuthorship W1969858462A5013219387 @default.
• W1969858462 hasAuthorship W1969858462A5028287372 @default.
• W1969858462 hasAuthorship W1969858462A5031604448 @default.
• W1969858462 hasAuthorship W1969858462A5036824051 @default.
• W1969858462 hasAuthorship W1969858462A5043253617 @default.
• W1969858462 hasAuthorship W1969858462A5052339023 @default.
• W1969858462 hasAuthorship W1969858462A5053914726 @default.
• W1969858462 hasAuthorship W1969858462A5069279463 @default.
• W1969858462 hasAuthorship W1969858462A5079163477 @default.
• W1969858462 hasAuthorship W1969858462A5081825821 @default.
• W1969858462 hasAuthorship W1969858462A5090779125 @default.
• W1969858462 hasAuthorship W1969858462A5091098368 @default.
• W1969858462 hasAuthorship W1969858462A5091296972 @default.
• W1969858462 hasBestOaLocation W19698584621 @default.
• W1969858462 hasConcept C104317684 @default.
• W1969858462 hasConcept C108249834 @default.
• W1969858462 hasConcept C121608353 @default.
• W1969858462 hasConcept C127561419 @default.
• W1969858462 hasConcept C147483822 @default.
• W1969858462 hasConcept C154317977 @default.
• W1969858462 hasConcept C167672396 @default.
• W1969858462 hasConcept C170627219 @default.
• W1969858462 hasConcept C202751555 @default.
• W1969858462 hasConcept C203014093 @default.

• next