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- W1969858593 abstract "The expression of the mdr1 gene was evaluated at the RNA level by northern and slot blot analysis, and at the protein level by immunohistochemistry, in a total of 29 bone and 32 soft tissue sarcomas. All patients, mainly adults, had not received previous chemotherapy. Of the tumours investigated, 69% were mdr1-positive. An intermediate mdr1 expression was observed most frequently, with the exception of osteosarcomas (high) and malignant fibrous histiocytomas (low). Detection of P-glycoprotein in selected tumours revealed consistent results. However, no conclusion can be drawn as yet regarding correlation of mdr1 expression and drug resistance in patients." @default.
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- W1969858593 date "1993-01-01" @default.
- W1969858593 modified "2023-10-16" @default.
- W1969858593 title "Expression of the mdr1 gene in bone and soft tissue sarcomas of adult patients" @default.
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- W1969858593 doi "https://doi.org/10.1016/0959-8049(93)90457-q" @default.
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