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- W1969883931 abstract "Jujuboside A (JuA), an effective component of sanzaoren, a Chinese herbal medicine, is a noncompetitive inhibitor of calmodulin (CaM). The interaction of JuA with CaM has been investigated with 1H NMR and spin-labeled EPR spectroscopies. The 1H NMR experiments showed that JuA has two kinds of binding sites on CaM: one locates in the N-terminus, the other locates in the C-terminal region of the polypeptide chain. The EPR studies on 5-maleimido-2,2,5,5-tetramethyl-1-pyrrolidinyloxyl labeled CaM (spin-labeled CaM) revealed that each CaM molecule can bind at least two JuA molecules. Binding of JuA affects the enviroments of some lysine residues (most likely Lys-74 and Lys-94), suggesting that JuA binds to CaM through hydrophobic interaction." @default.
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- W1969883931 date "1994-07-01" @default.
- W1969883931 modified "2023-10-16" @default.
- W1969883931 title "1H NMR and Spin-Labeled EPR Studies on the Interaction of Calmodulin with Jujuboside A" @default.
- W1969883931 doi "https://doi.org/10.1006/bbrc.1994.1905" @default.
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