FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969888906> ?p ?o ?g. }

• W1969888906 endingPage "886" @default.
• W1969888906 startingPage "873" @default.
• W1969888906 abstract "Trex1 is the major 3′ DNA exonuclease in mammalian cells, and mutations in the human TREX1 gene can cause Aicardi-Goutières syndrome, characterized by perturbed immunity. Similarly, Trex1−/− mice have an autoinflammatory phenotype; however, the mechanism of Trex1-deficient disease is unknown. We report that Trex1, ordinarily associated with the endoplasmic reticulum (ER), relocalizes to the S phase nucleus after γ irradiation or hydroxyurea treatment. Notably, Trex1-deficient cells show defective G1/S transition and chronic ATM-dependent checkpoint activation, even in the absence of exogenous stress, correlating with persistent single-stranded DNA molecules produced in S phase, which accumulate in the ER. Our data indicate that Trex1 acts on a single-stranded DNA polynucleotide species generated from processing of aberrant replication intermediates to attenuate DNA damage checkpoint signaling and prevent pathological immune activation." @default.
• W1969888906 created "2016-06-24" @default.
• W1969888906 creator A5032524881 @default.
• W1969888906 creator A5052037541 @default.
• W1969888906 creator A5060285944 @default.
• W1969888906 date "2007-11-01" @default.
• W1969888906 modified "2023-10-09" @default.
• W1969888906 title "Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease" @default.
• W1969888906 cites W1964622938 @default.
• W1969888906 cites W1966219094 @default.
• W1969888906 cites W1968552183 @default.
• W1969888906 cites W1969464492 @default.
• W1969888906 cites W1969824361 @default.
• W1969888906 cites W1970227011 @default.
• W1969888906 cites W1970291282 @default.
• W1969888906 cites W1970436496 @default.
• W1969888906 cites W1971476329 @default.
• W1969888906 cites W1976781795 @default.
• W1969888906 cites W1988388573 @default.
• W1969888906 cites W1990198168 @default.
• W1969888906 cites W1992897184 @default.
• W1969888906 cites W1997149034 @default.
• W1969888906 cites W2004648009 @default.
• W1969888906 cites W2010757393 @default.
• W1969888906 cites W2015519364 @default.
• W1969888906 cites W2015925058 @default.
• W1969888906 cites W2032076692 @default.
• W1969888906 cites W2034487221 @default.
• W1969888906 cites W2037845691 @default.
• W1969888906 cites W2043312677 @default.
• W1969888906 cites W2043895957 @default.
• W1969888906 cites W2043959346 @default.
• W1969888906 cites W2044246914 @default.
• W1969888906 cites W2044886076 @default.
• W1969888906 cites W2046066638 @default.
• W1969888906 cites W2055667487 @default.
• W1969888906 cites W2057980850 @default.
• W1969888906 cites W2062080272 @default.
• W1969888906 cites W2064256444 @default.
• W1969888906 cites W2068992336 @default.
• W1969888906 cites W2069550453 @default.
• W1969888906 cites W2075172390 @default.
• W1969888906 cites W2076690763 @default.
• W1969888906 cites W2085866527 @default.
• W1969888906 cites W2089083932 @default.
• W1969888906 cites W2089218510 @default.
• W1969888906 cites W2094472716 @default.
• W1969888906 cites W2095206600 @default.
• W1969888906 cites W2100817243 @default.
• W1969888906 cites W2101988823 @default.
• W1969888906 cites W2105819314 @default.
• W1969888906 cites W2119059077 @default.
• W1969888906 cites W2130449325 @default.
• W1969888906 cites W2133779525 @default.
• W1969888906 cites W2145812105 @default.
• W1969888906 cites W2146230109 @default.
• W1969888906 cites W2157435389 @default.
• W1969888906 cites W2159579808 @default.
• W1969888906 cites W2165336005 @default.
• W1969888906 cites W2169911836 @default.
• W1969888906 cites W2169933147 @default.
• W1969888906 cites W2171763930 @default.
• W1969888906 cites W2171946670 @default.
• W1969888906 cites W2183878692 @default.
• W1969888906 doi "https://doi.org/10.1016/j.cell.2007.10.017" @default.
• W1969888906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18045533" @default.
• W1969888906 hasPublicationYear "2007" @default.
• W1969888906 type Work @default.
• W1969888906 sameAs 1969888906 @default.
• W1969888906 citedByCount "485" @default.
• W1969888906 countsByYear W19698889062012 @default.
• W1969888906 countsByYear W19698889062013 @default.
• W1969888906 countsByYear W19698889062014 @default.
• W1969888906 countsByYear W19698889062015 @default.
• W1969888906 countsByYear W19698889062016 @default.
• W1969888906 countsByYear W19698889062017 @default.
• W1969888906 countsByYear W19698889062018 @default.
• W1969888906 countsByYear W19698889062019 @default.
• W1969888906 countsByYear W19698889062020 @default.
• W1969888906 countsByYear W19698889062021 @default.
• W1969888906 countsByYear W19698889062022 @default.
• W1969888906 countsByYear W19698889062023 @default.
• W1969888906 crossrefType "journal-article" @default.
• W1969888906 hasAuthorship W1969888906A5032524881 @default.
• W1969888906 hasAuthorship W1969888906A5052037541 @default.
• W1969888906 hasAuthorship W1969888906A5060285944 @default.
• W1969888906 hasBestOaLocation W19698889061 @default.
• W1969888906 hasConcept C104317684 @default.
• W1969888906 hasConcept C105696609 @default.
• W1969888906 hasConcept C143425029 @default.
• W1969888906 hasConcept C153911025 @default.
• W1969888906 hasConcept C158617107 @default.
• W1969888906 hasConcept C2756471 @default.
• W1969888906 hasConcept C2777501222 @default.
• W1969888906 hasConcept C29537977 @default.
• W1969888906 hasConcept C54086632 @default.
• W1969888906 hasConcept C54355233 @default.
• W1969888906 hasConcept C552990157 @default.

• next