Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969893918> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W1969893918 abstract "We were interested to read the paper by Shephard et al1 on the clinical features of bladder cancer in primary care, as we have previously published a paper2 in the BJGP where we reported on symptoms associated with renal tract cancer (of which around 80% were bladder cancers) in primary care. Both studies evaluated the risk or positive predictive value of symptoms for detecting cases of cancer, and both used UK primary care databases, but the study designs were different with Shepherd et al using a case-control approach while we used a cohort design.A key finding of both studies is that haematuria is a strong predictor of bladder/renal cancer, with a stronger association at younger ages. Indeed we reported that around three-quarters of renal cancer cases had reported haematuria before their diagnosis. Both studies also found at least a doubling of risk in people consulting with abdominal pain. A strength of our study design was that we were able to combine the risks associated with the different symptoms and clinical features with the established risks associated with smoking, into an algorithm that can predict absolute risk in individuals presenting with symptoms. We also accounted for the steep increases in risk with age and for different risks in men and women, since rates in men are at least three times higher than in women. Crucially we validated this algorithm in a separate cohort of patients, and found that it discriminated extremely well between cancer cases and the remainder of the cohort (ROC values of 0.95 in men and 0.91 in women). The 10% of patients with highest risks contained 87% of all renal cancers diagnosed within 2 years. It is unclear how many cancer cases would be detected using the approach of Shepherd et al, nor is there any validation on an external dataset which is an essential step needed to determine whether the results are valuable.3" @default.
- W1969893918 created "2016-06-24" @default.
- W1969893918 creator A5004448187 @default.
- W1969893918 creator A5080823270 @default.
- W1969893918 date "2012-11-01" @default.
- W1969893918 modified "2023-09-30" @default.
- W1969893918 title "Predicting risk of bladder cancer in the UK" @default.
- W1969893918 cites W1983526535 @default.
- W1969893918 cites W2082376914 @default.
- W1969893918 cites W4255923576 @default.
- W1969893918 doi "https://doi.org/10.3399/bjgp12x658160" @default.
- W1969893918 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3481492" @default.
- W1969893918 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23211155" @default.
- W1969893918 hasPublicationYear "2012" @default.
- W1969893918 type Work @default.
- W1969893918 sameAs 1969893918 @default.
- W1969893918 citedByCount "0" @default.
- W1969893918 crossrefType "journal-article" @default.
- W1969893918 hasAuthorship W1969893918A5004448187 @default.
- W1969893918 hasAuthorship W1969893918A5080823270 @default.
- W1969893918 hasBestOaLocation W19698939181 @default.
- W1969893918 hasConcept C121608353 @default.
- W1969893918 hasConcept C126322002 @default.
- W1969893918 hasConcept C201903717 @default.
- W1969893918 hasConcept C2780352672 @default.
- W1969893918 hasConcept C29456083 @default.
- W1969893918 hasConcept C2984752397 @default.
- W1969893918 hasConcept C512399662 @default.
- W1969893918 hasConcept C71924100 @default.
- W1969893918 hasConcept C72563966 @default.
- W1969893918 hasConceptScore W1969893918C121608353 @default.
- W1969893918 hasConceptScore W1969893918C126322002 @default.
- W1969893918 hasConceptScore W1969893918C201903717 @default.
- W1969893918 hasConceptScore W1969893918C2780352672 @default.
- W1969893918 hasConceptScore W1969893918C29456083 @default.
- W1969893918 hasConceptScore W1969893918C2984752397 @default.
- W1969893918 hasConceptScore W1969893918C512399662 @default.
- W1969893918 hasConceptScore W1969893918C71924100 @default.
- W1969893918 hasConceptScore W1969893918C72563966 @default.
- W1969893918 hasLocation W19698939181 @default.
- W1969893918 hasLocation W19698939182 @default.
- W1969893918 hasLocation W19698939183 @default.
- W1969893918 hasLocation W19698939184 @default.
- W1969893918 hasOpenAccess W1969893918 @default.
- W1969893918 hasPrimaryLocation W19698939181 @default.
- W1969893918 hasRelatedWork W1562998603 @default.
- W1969893918 hasRelatedWork W1842751601 @default.
- W1969893918 hasRelatedWork W2051051561 @default.
- W1969893918 hasRelatedWork W2069419852 @default.
- W1969893918 hasRelatedWork W2073135171 @default.
- W1969893918 hasRelatedWork W2073694594 @default.
- W1969893918 hasRelatedWork W2080344756 @default.
- W1969893918 hasRelatedWork W2091796448 @default.
- W1969893918 hasRelatedWork W2095531282 @default.
- W1969893918 hasRelatedWork W2117165272 @default.
- W1969893918 hasRelatedWork W2141827707 @default.
- W1969893918 hasRelatedWork W2147728537 @default.
- W1969893918 hasRelatedWork W2170209084 @default.
- W1969893918 hasRelatedWork W2411630239 @default.
- W1969893918 hasRelatedWork W2413239382 @default.
- W1969893918 hasRelatedWork W2603865964 @default.
- W1969893918 hasRelatedWork W2796127306 @default.
- W1969893918 hasRelatedWork W2952738767 @default.
- W1969893918 hasRelatedWork W2970591136 @default.
- W1969893918 hasRelatedWork W2982766258 @default.
- W1969893918 isParatext "false" @default.
- W1969893918 isRetracted "false" @default.
- W1969893918 magId "1969893918" @default.
- W1969893918 workType "article" @default.