FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969896605> ?p ?o ?g. }

• W1969896605 endingPage "e8313" @default.
• W1969896605 startingPage "e8313" @default.
• W1969896605 abstract "The aim of this study was to describe treatment outcomes for multi-drug resistant tuberculosis (MDR-TB) outpatients on a standardized regimen in Nepal.Data on pulmonary MDR-TB patients enrolled for treatment in the Green Light Committee-approved National Programme between 15 September 2005 and 15 September 2006 were studied. Standardized regimen was used (8Z-Km-Ofx-Eto-Cs/16Z-Ofx-Eto-Cs) for a maximum of 32 months and follow-up was by smear and culture. Drug susceptibility testing (DST) results were not used to modify the treatment regimen. MDR-TB therapy was delivered in outpatient facilities for the whole course of treatment. Multivariable analysis was used to explain bacteriological cure as a function of sex, age, initial body weight, history of previous treatment and the region of report.In the first 12-months, 175 laboratory-confirmed MDR-TB cases (62% males) had outcomes reported. Most cases had failed a Category 2 first-line regimen (87%) or a Category 1 regimen (6%), 2% were previously untreated contacts of MDR-TB cases and 5% were unspecified. Cure was reported among 70% of patients (range 38%-93% by Region), 8% died, 5% failed treatment, and 17% defaulted. Unfavorable outcomes were not correlated to the number of resistant drugs at baseline DST. Cases who died had a lower mean body weight than those surviving (40.3 kg vs 47.2 kg, p<0.05). Default was significantly higher in two regions [Eastern OR = 6.2; 95%CL2.0-18.9; Far West OR = 5.0; 95%CL1.0-24.3]. At logistic regression, cure was inversely associated with body weight <36 kg [Adj.OR = 0.1; 95%CL0.0-0.3; ref. 55-75 kg] and treatment in the Eastern region [Adj.OR = 0.1; 95%CL0.0-0.4; ref. Central region].The implementation of an ambulatory-based treatment programme for MDR-TB based on a fully standardized regimen can yield high cure rates even in resource-limited settings. The determinants of unfavorable outcome should be investigated thoroughly to maximize likelihood of successful treatment." @default.
• W1969896605 created "2016-06-24" @default.
• W1969896605 creator A5017791670 @default.
• W1969896605 creator A5028774255 @default.
• W1969896605 creator A5041863289 @default.
• W1969896605 creator A5041992622 @default.
• W1969896605 creator A5049456427 @default.
• W1969896605 creator A5051964033 @default.
• W1969896605 creator A5052385625 @default.
• W1969896605 creator A5054911822 @default.
• W1969896605 creator A5057470515 @default.
• W1969896605 creator A5070944467 @default.
• W1969896605 creator A5082052842 @default.
• W1969896605 creator A5090794543 @default.
• W1969896605 date "2009-12-23" @default.
• W1969896605 modified "2023-09-30" @default.
• W1969896605 title "Ambulatory-Based Standardized Therapy for Multi-Drug Resistant Tuberculosis: Experience from Nepal, 2005–2006" @default.
• W1969896605 cites W1219937251 @default.
• W1969896605 cites W1720252267 @default.
• W1969896605 cites W19265322 @default.
• W1969896605 cites W1966243392 @default.
• W1969896605 cites W1974359669 @default.
• W1969896605 cites W2014321835 @default.
• W1969896605 cites W2097385715 @default.
• W1969896605 cites W2112718676 @default.
• W1969896605 cites W2124127309 @default.
• W1969896605 cites W2127258416 @default.
• W1969896605 cites W2127884570 @default.
• W1969896605 cites W2135027892 @default.
• W1969896605 cites W2136694704 @default.
• W1969896605 cites W2142447693 @default.
• W1969896605 cites W2154753506 @default.
• W1969896605 cites W2262309301 @default.
• W1969896605 cites W34345062 @default.
• W1969896605 cites W1997662775 @default.
• W1969896605 doi "https://doi.org/10.1371/journal.pone.0008313" @default.
• W1969896605 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2794372" @default.
• W1969896605 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20041140" @default.
• W1969896605 hasPublicationYear "2009" @default.
• W1969896605 type Work @default.
• W1969896605 sameAs 1969896605 @default.
• W1969896605 citedByCount "42" @default.
• W1969896605 countsByYear W19698966052012 @default.
• W1969896605 countsByYear W19698966052013 @default.
• W1969896605 countsByYear W19698966052014 @default.
• W1969896605 countsByYear W19698966052015 @default.
• W1969896605 countsByYear W19698966052016 @default.
• W1969896605 countsByYear W19698966052017 @default.
• W1969896605 countsByYear W19698966052018 @default.
• W1969896605 countsByYear W19698966052019 @default.
• W1969896605 countsByYear W19698966052020 @default.
• W1969896605 countsByYear W19698966052021 @default.
• W1969896605 crossrefType "journal-article" @default.
• W1969896605 hasAuthorship W1969896605A5017791670 @default.
• W1969896605 hasAuthorship W1969896605A5028774255 @default.
• W1969896605 hasAuthorship W1969896605A5041863289 @default.
• W1969896605 hasAuthorship W1969896605A5041992622 @default.
• W1969896605 hasAuthorship W1969896605A5049456427 @default.
• W1969896605 hasAuthorship W1969896605A5051964033 @default.
• W1969896605 hasAuthorship W1969896605A5052385625 @default.
• W1969896605 hasAuthorship W1969896605A5054911822 @default.
• W1969896605 hasAuthorship W1969896605A5057470515 @default.
• W1969896605 hasAuthorship W1969896605A5070944467 @default.
• W1969896605 hasAuthorship W1969896605A5082052842 @default.
• W1969896605 hasAuthorship W1969896605A5090794543 @default.
• W1969896605 hasBestOaLocation W19698966051 @default.
• W1969896605 hasConcept C126322002 @default.
• W1969896605 hasConcept C141071460 @default.
• W1969896605 hasConcept C142724271 @default.
• W1969896605 hasConcept C187212893 @default.
• W1969896605 hasConcept C2776301714 @default.
• W1969896605 hasConcept C2777025531 @default.
• W1969896605 hasConcept C2777768864 @default.
• W1969896605 hasConcept C2777975735 @default.
• W1969896605 hasConcept C2781069245 @default.
• W1969896605 hasConcept C2781413609 @default.
• W1969896605 hasConcept C500440147 @default.
• W1969896605 hasConcept C71924100 @default.
• W1969896605 hasConceptScore W1969896605C126322002 @default.
• W1969896605 hasConceptScore W1969896605C141071460 @default.
• W1969896605 hasConceptScore W1969896605C142724271 @default.
• W1969896605 hasConceptScore W1969896605C187212893 @default.
• W1969896605 hasConceptScore W1969896605C2776301714 @default.
• W1969896605 hasConceptScore W1969896605C2777025531 @default.
• W1969896605 hasConceptScore W1969896605C2777768864 @default.
• W1969896605 hasConceptScore W1969896605C2777975735 @default.
• W1969896605 hasConceptScore W1969896605C2781069245 @default.
• W1969896605 hasConceptScore W1969896605C2781413609 @default.
• W1969896605 hasConceptScore W1969896605C500440147 @default.
• W1969896605 hasConceptScore W1969896605C71924100 @default.
• W1969896605 hasIssue "12" @default.
• W1969896605 hasLocation W19698966051 @default.
• W1969896605 hasLocation W19698966052 @default.
• W1969896605 hasLocation W19698966053 @default.
• W1969896605 hasLocation W19698966054 @default.
• W1969896605 hasOpenAccess W1969896605 @default.
• W1969896605 hasPrimaryLocation W19698966051 @default.
• W1969896605 hasRelatedWork W2002113121 @default.

• next