FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969897024> ?p ?o ?g. }

• W1969897024 endingPage "40" @default.
• W1969897024 startingPage "29" @default.
• W1969897024 abstract "Infants of epileptic women treated with valproic acid (VPA) during pregnancy have a higher risk of developing spina bifida than those of the general population. VPA induces exencephaly in experimental animal embryos. But the pathogenetic mechanism remains rather elusive. Antiepileptic drugs (AED) in general accentuate pregnancy-imposed fall in maternal folate levels. Periconceptional folic acid supplementation is reported to protect embryos from developing neural tube defects (NTD). Conflicting results have been reported by experimental studies that attempted to alleviate VPA-induced NTD by folic acid. Our objectives were to determine the critical developmental stages and an effective dose of folic acid for the prevention of VPA-induced exencephaly in mouse fetuses. A single teratogenic dose of 400 mg/kg of VPA was administered to TO mice on gestation day (GD) 7 or 8. It was followed by (1) a single dose of 12 mg/kg of FA (folinic acid) or (2) 3 doses of FA 4 mg/kg each. In experiment (3), FA (4 mg/kg) was administered thrice daily starting on GD 5 and continued through GD 10. These animals received VPA on GD 7 or 8. VPA and B12 concentrations were determined by radioimmunoassay. The single heavy dose of FA had no rescue effect on NTD. Three divided doses of FA on GD 7 and continuous dosing of FA from GD 5 through GD 10 substantially reduced the VPA-induced exencephaly in the fetuses. In the later experiments, the neural folds elevated faster than the non-supplemented group. VPA considerably reduced maternal plasma folate and B12 concentrations. The heavy dose of FA only moderately improved vitamin levels. Three divided doses of FA elevated the vitamin levels slightly better but it was the prolonged dosing of FA that was associated with sustained elevation of plasma levels higher than the control levels and acceleration of neural tube closure thus accounting for the pronounced protection against VPA-induced NTD development. These data suggest that plasma levels of FA and B12 have to be kept substantially elevated and maintained high throughout organogenesis period to protect embryos against VPA-induced NTD in this mouse model." @default.
• W1969897024 created "2016-06-24" @default.
• W1969897024 creator A5056988791 @default.
• W1969897024 creator A5079847006 @default.
• W1969897024 date "2003-03-01" @default.
• W1969897024 modified "2023-09-26" @default.
• W1969897024 title "Amelioration of sodium valproate-induced neural tube defects in mouse fetuses by maternal folic acid supplementation during gestation" @default.
• W1969897024 cites W1807067246 @default.
• W1969897024 cites W1901623573 @default.
• W1969897024 cites W1966880658 @default.
• W1969897024 cites W1975671571 @default.
• W1969897024 cites W1981740099 @default.
• W1969897024 cites W1987576469 @default.
• W1969897024 cites W1988150535 @default.
• W1969897024 cites W1988871728 @default.
• W1969897024 cites W1991661434 @default.
• W1969897024 cites W1996348880 @default.
• W1969897024 cites W1999366195 @default.
• W1969897024 cites W2003424583 @default.
• W1969897024 cites W2010563337 @default.
• W1969897024 cites W2013205305 @default.
• W1969897024 cites W2013932511 @default.
• W1969897024 cites W2014104304 @default.
• W1969897024 cites W2014151799 @default.
• W1969897024 cites W2022646117 @default.
• W1969897024 cites W2024059401 @default.
• W1969897024 cites W2029055025 @default.
• W1969897024 cites W2029643287 @default.
• W1969897024 cites W2034027244 @default.
• W1969897024 cites W2039806274 @default.
• W1969897024 cites W2043533487 @default.
• W1969897024 cites W2044634496 @default.
• W1969897024 cites W2045297515 @default.
• W1969897024 cites W2046544714 @default.
• W1969897024 cites W2047732548 @default.
• W1969897024 cites W2051114207 @default.
• W1969897024 cites W2055942057 @default.
• W1969897024 cites W2061727772 @default.
• W1969897024 cites W2063440973 @default.
• W1969897024 cites W2069065010 @default.
• W1969897024 cites W2070236076 @default.
• W1969897024 cites W2070649097 @default.
• W1969897024 cites W2071168297 @default.
• W1969897024 cites W2072353831 @default.
• W1969897024 cites W2073097537 @default.
• W1969897024 cites W2079189194 @default.
• W1969897024 cites W2079565780 @default.
• W1969897024 cites W2085755912 @default.
• W1969897024 cites W2089647449 @default.
• W1969897024 cites W2094884348 @default.
• W1969897024 cites W2095914095 @default.
• W1969897024 cites W2099368520 @default.
• W1969897024 cites W2113146832 @default.
• W1969897024 cites W2120680518 @default.
• W1969897024 cites W2126405176 @default.
• W1969897024 cites W2132576272 @default.
• W1969897024 cites W2133486359 @default.
• W1969897024 cites W2140622819 @default.
• W1969897024 cites W2142465069 @default.
• W1969897024 cites W2159299174 @default.
• W1969897024 cites W2168594743 @default.
• W1969897024 cites W2316436146 @default.
• W1969897024 cites W2325417132 @default.
• W1969897024 cites W2328335865 @default.
• W1969897024 cites W2332062453 @default.
• W1969897024 cites W2332426614 @default.
• W1969897024 cites W2427655070 @default.
• W1969897024 cites W4237533794 @default.
• W1969897024 doi "https://doi.org/10.1111/j.1399-0004.2003.tb02304.x" @default.
• W1969897024 hasPublicationYear "2003" @default.
• W1969897024 type Work @default.
• W1969897024 sameAs 1969897024 @default.
• W1969897024 citedByCount "0" @default.
• W1969897024 crossrefType "journal-article" @default.
• W1969897024 hasAuthorship W1969897024A5056988791 @default.
• W1969897024 hasAuthorship W1969897024A5079847006 @default.
• W1969897024 hasConcept C126322002 @default.
• W1969897024 hasConcept C131872663 @default.
• W1969897024 hasConcept C134018914 @default.
• W1969897024 hasConcept C172680121 @default.
• W1969897024 hasConcept C196843134 @default.
• W1969897024 hasConcept C2777003008 @default.
• W1969897024 hasConcept C2779234561 @default.
• W1969897024 hasConcept C2780594696 @default.
• W1969897024 hasConcept C2992130864 @default.
• W1969897024 hasConcept C46973012 @default.
• W1969897024 hasConcept C54355233 @default.
• W1969897024 hasConcept C71924100 @default.
• W1969897024 hasConcept C86803240 @default.
• W1969897024 hasConcept C95444343 @default.
• W1969897024 hasConceptScore W1969897024C126322002 @default.
• W1969897024 hasConceptScore W1969897024C131872663 @default.
• W1969897024 hasConceptScore W1969897024C134018914 @default.
• W1969897024 hasConceptScore W1969897024C172680121 @default.
• W1969897024 hasConceptScore W1969897024C196843134 @default.
• W1969897024 hasConceptScore W1969897024C2777003008 @default.
• W1969897024 hasConceptScore W1969897024C2779234561 @default.
• W1969897024 hasConceptScore W1969897024C2780594696 @default.

• next