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- W1969898169 abstract "The recent availability of large-scale sequencing DNA data allowed researchers to investigate how genomic variation is distributed among populations. While demographic factors explain genome-wide population genetic diversity levels, scans for signatures of natural selection pinpointed several regions under non-neutral evolution. Recent studies found an enrichment of immune-related genes subjected to natural selection, suggesting that pathogens and infectious diseases have imposed a strong selective pressure throughout human history. Pathogen-mediated selection often targeted regulatory sites of genes belonging to the same biological pathway. Results from these studies have the potential to identify mutations that modulate infection susceptibility by integrating a population genomic approach with molecular immunology data and large-scale functional annotations." @default.
- W1969898169 created "2016-06-24" @default.
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- W1969898169 date "2014-10-01" @default.
- W1969898169 modified "2023-09-24" @default.
- W1969898169 title "Human genome variability, natural selection and infectious diseases" @default.
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- W1969898169 doi "https://doi.org/10.1016/j.coi.2014.05.001" @default.
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