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- W1969898251 abstract "The analgesic effect of Botulinum toxin A has been already demonstrated in different experimental models of pain. The aim of the present study was to compare the efficacy of Dysport® and Botox® on inflammatory pain induced in rats by a sub-plantar (s.p.) injection of carrageenan (2 mg/0.1 ml) in the right hind paw. Hyperalgesia was assessed by measurement of the withdrawal threshold of each hind paw in response to mechanical stimulus (Randall & Selitto pressure test). In this model, Dysport® and Botox® elicited a comparable analgesic effect (ED50: 22 and 28 U/kg, respectively) when administered (s.p.) in the right hind paw 3 days before carrageenan administration. In this model, intraperitoneal injection of morphine induced a dose-dependent analgesic effect with an ED50 of 0.6 mg/kg. When a non-active dose of morphine (0.3 mg/kg) was tested in animals pre-treated 3 days before with a non-active dose of Dysport® (10 U/kg), a significant analgesic effect was observed. Considering that large doses of morphine result in side effects and tolerance, this result suggests that Botulinum toxin A may have morphine sparing effects." @default.
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- W1969898251 date "2008-06-01" @default.
- W1969898251 modified "2023-09-27" @default.
- W1969898251 title "Analgesic effects of Botulinum toxin A in an inflammatory pain model in rats: Comparison of Dysport® and Botox®; synergistic interaction with morphine" @default.
- W1969898251 doi "https://doi.org/10.1016/j.toxicon.2008.04.026" @default.
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