FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969899814> ?p ?o ?g. }

• W1969899814 endingPage "894" @default.
• W1969899814 startingPage "879" @default.
• W1969899814 abstract "Abstract During development neural progenitor cells migrate with extraordinary precision to inhabit tissues and organs far from their initial position. Little is known about the cellular basis for directional guidance by tyrosine kinase receptors (RTKs). RET is a RTK with important functions in guiding the migration of neuronal cells, and RET dysregulation leads to clinical disease such as agangliosis of the colon. We show here that RET migration in neuroepitheliomal and non‐neuronal cells is elicited by the activation of specific signaling pathways initiated by the competitive recruitment of the FRS2 adaptor molecule to tyrosine 1062 (Y1062) in RET. FRS2 selectively recruited RET to focal complexes and led to activation of SRC family kinases and focal adhesion kinase (FAK). Activation of SRC depended on its direct interaction with RET at a different intracellular tyrosine (Y981) and activation of molecular signaling from these two separate sites in concert regulated migration. Our data suggest that an important function for FRS2 is to concentrate RET in membrane foci, leading to an engagement of specific signaling complexes localized in these membrane domains. J. Cell. Biochem. 104: 879–894, 2008. © 2008 Wiley‐Liss, Inc." @default.
• W1969899814 created "2016-06-24" @default.
• W1969899814 creator A5004312566 @default.
• W1969899814 creator A5017672763 @default.
• W1969899814 creator A5023864554 @default.
• W1969899814 creator A5056987706 @default.
• W1969899814 creator A5077093856 @default.
• W1969899814 date "2008-01-11" @default.
• W1969899814 modified "2023-10-06" @default.
• W1969899814 title "Cell migration by a FRS2-adaptor dependent membrane relocation of ret receptors" @default.
• W1969899814 cites W1522989648 @default.
• W1969899814 cites W1577573926 @default.
• W1969899814 cites W161143260 @default.
• W1969899814 cites W1964020745 @default.
• W1969899814 cites W1968517866 @default.
• W1969899814 cites W1968640414 @default.
• W1969899814 cites W1971106165 @default.
• W1969899814 cites W1972172786 @default.
• W1969899814 cites W1972515739 @default.
• W1969899814 cites W1985885351 @default.
• W1969899814 cites W1988477421 @default.
• W1969899814 cites W1996268443 @default.
• W1969899814 cites W2006060580 @default.
• W1969899814 cites W2011838710 @default.
• W1969899814 cites W2012912004 @default.
• W1969899814 cites W2014280822 @default.
• W1969899814 cites W2016730284 @default.
• W1969899814 cites W2017670681 @default.
• W1969899814 cites W2020910328 @default.
• W1969899814 cites W2024372419 @default.
• W1969899814 cites W2028691987 @default.
• W1969899814 cites W2031546058 @default.
• W1969899814 cites W2034739637 @default.
• W1969899814 cites W2035501941 @default.
• W1969899814 cites W2039395955 @default.
• W1969899814 cites W2041095748 @default.
• W1969899814 cites W2044895919 @default.
• W1969899814 cites W2048209624 @default.
• W1969899814 cites W2050904439 @default.
• W1969899814 cites W2051878311 @default.
• W1969899814 cites W2055236991 @default.
• W1969899814 cites W2059177632 @default.
• W1969899814 cites W2063220206 @default.
• W1969899814 cites W2069180517 @default.
• W1969899814 cites W2069398477 @default.
• W1969899814 cites W2073412279 @default.
• W1969899814 cites W2075945988 @default.
• W1969899814 cites W2085412371 @default.
• W1969899814 cites W2089396478 @default.
• W1969899814 cites W2089920144 @default.
• W1969899814 cites W2090061589 @default.
• W1969899814 cites W2090109575 @default.
• W1969899814 cites W2090895449 @default.
• W1969899814 cites W2094173028 @default.
• W1969899814 cites W2095639798 @default.
• W1969899814 cites W2097557938 @default.
• W1969899814 cites W2101257013 @default.
• W1969899814 cites W2103087982 @default.
• W1969899814 cites W2104281780 @default.
• W1969899814 cites W2105946812 @default.
• W1969899814 cites W2113873325 @default.
• W1969899814 cites W2117923185 @default.
• W1969899814 cites W2121038814 @default.
• W1969899814 cites W2124386542 @default.
• W1969899814 cites W2132755748 @default.
• W1969899814 cites W2135546209 @default.
• W1969899814 cites W2135776211 @default.
• W1969899814 cites W2147581277 @default.
• W1969899814 cites W2150125913 @default.
• W1969899814 cites W2150759777 @default.
• W1969899814 cites W2152807205 @default.
• W1969899814 cites W2152963416 @default.
• W1969899814 cites W2153177392 @default.
• W1969899814 cites W2315338108 @default.
• W1969899814 doi "https://doi.org/10.1002/jcb.21671" @default.
• W1969899814 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18189271" @default.
• W1969899814 hasPublicationYear "2008" @default.
• W1969899814 type Work @default.
• W1969899814 sameAs 1969899814 @default.
• W1969899814 citedByCount "4" @default.
• W1969899814 countsByYear W19698998142012 @default.
• W1969899814 crossrefType "journal-article" @default.
• W1969899814 hasAuthorship W1969899814A5004312566 @default.
• W1969899814 hasAuthorship W1969899814A5017672763 @default.
• W1969899814 hasAuthorship W1969899814A5023864554 @default.
• W1969899814 hasAuthorship W1969899814A5056987706 @default.
• W1969899814 hasAuthorship W1969899814A5077093856 @default.
• W1969899814 hasConcept C101544691 @default.
• W1969899814 hasConcept C108636557 @default.
• W1969899814 hasConcept C137738243 @default.
• W1969899814 hasConcept C1491633281 @default.
• W1969899814 hasConcept C151166631 @default.
• W1969899814 hasConcept C183786373 @default.
• W1969899814 hasConcept C185592680 @default.
• W1969899814 hasConcept C42362537 @default.
• W1969899814 hasConcept C502942594 @default.
• W1969899814 hasConcept C55493867 @default.
• W1969899814 hasConcept C62478195 @default.

• next