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- W1969901275 abstract "Lipopolysaccharide binding protein (LBP) has a well-established role in LPS-induced immune responses. Here, we report that LBP also plays an essential role in the innate immune response to Gram-positive pneumococci, specifically to their major inflammatory component, pneumococcal cell wall (PCW). LBP was present in the CSF of patients with meningitis, and LBP-deficient mice failed to develop meningeal inflammation. LBP enhanced PCW-induced cell signaling and TNF-α release. LBP bound specifically to PCW multimers, indicating novel lipid-independent binding capability for LBP. We propose the iterative anionic groups along the glycan backbone of the cell wall are a crucial structure for recognition by LBP. Such a function for LBP expands its role to Gram-positive infections." @default.
- W1969901275 created "2016-06-24" @default.
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- W1969901275 date "2003-08-01" @default.
- W1969901275 modified "2023-10-11" @default.
- W1969901275 title "Recognition of Pneumococcal Peptidoglycan" @default.
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- W1969901275 doi "https://doi.org/10.1016/s1074-7613(03)00205-x" @default.
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