Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969901690> ?p ?o ?g. }
- W1969901690 endingPage "1425" @default.
- W1969901690 startingPage "1418" @default.
- W1969901690 abstract "Sequence polymorphism has been reported for virtually all malaria antigens and, in the case of the circumsporozoite (CS) protein, this variation is in the form of point mutations concentrated primarily in several regions recognized by T cells. The factors responsible for the variation are unknown. We studied the T cell responses to all known variants in malaria-exposed Thais. Memory CD4+ T cells responded to variants of a polymorphic immunodominant region (denoted Th2R), and CD4+ T cell clones specific for one Thai Th2R variant were generated. There was minimal cross-reactivity to any of the naturally occurring variants, including the other Thai variant, and competition studies performed with the clones using analog peptides demonstrated that all the substitutions of the polymorphic residues modulate either the binding of the peptide to major histocompatibility complex (MHC) molecules or the recognition by the T cell receptor of the peptide-MHC complex. Our data suggest that CD4+ T cells may be able to select parasites expressing variant sequences and have implications for development of a CS-based vaccine." @default.
- W1969901690 created "2016-06-24" @default.
- W1969901690 creator A5002675485 @default.
- W1969901690 creator A5035536310 @default.
- W1969901690 creator A5050552080 @default.
- W1969901690 date "1994-06-01" @default.
- W1969901690 modified "2023-09-23" @default.
- W1969901690 title "Natural amino acid polymorphisms of the circumsporozoite protein ofPlasmodium falciparum abrogate specific human CD4+ T cell responsiveness" @default.
- W1969901690 cites W1502880726 @default.
- W1969901690 cites W1522894100 @default.
- W1969901690 cites W1530729824 @default.
- W1969901690 cites W1554306792 @default.
- W1969901690 cites W1576644001 @default.
- W1969901690 cites W1595789911 @default.
- W1969901690 cites W1606113013 @default.
- W1969901690 cites W1606480448 @default.
- W1969901690 cites W1630764064 @default.
- W1969901690 cites W1648233548 @default.
- W1969901690 cites W1791909250 @default.
- W1969901690 cites W1831091904 @default.
- W1969901690 cites W1849892318 @default.
- W1969901690 cites W187920822 @default.
- W1969901690 cites W1889158463 @default.
- W1969901690 cites W1890107338 @default.
- W1969901690 cites W1967748798 @default.
- W1969901690 cites W1971932612 @default.
- W1969901690 cites W1972235351 @default.
- W1969901690 cites W1979286771 @default.
- W1969901690 cites W1991089024 @default.
- W1969901690 cites W2002947112 @default.
- W1969901690 cites W2004073746 @default.
- W1969901690 cites W2004979064 @default.
- W1969901690 cites W2006488418 @default.
- W1969901690 cites W2008944970 @default.
- W1969901690 cites W2014595456 @default.
- W1969901690 cites W2014916785 @default.
- W1969901690 cites W2014923037 @default.
- W1969901690 cites W2020231058 @default.
- W1969901690 cites W2030302205 @default.
- W1969901690 cites W2033090330 @default.
- W1969901690 cites W2036007789 @default.
- W1969901690 cites W2044112812 @default.
- W1969901690 cites W2045377848 @default.
- W1969901690 cites W2058071227 @default.
- W1969901690 cites W2066905955 @default.
- W1969901690 cites W2070457810 @default.
- W1969901690 cites W2073557509 @default.
- W1969901690 cites W2074407786 @default.
- W1969901690 cites W2079688453 @default.
- W1969901690 cites W2084111712 @default.
- W1969901690 cites W2088135194 @default.
- W1969901690 cites W2093112138 @default.
- W1969901690 cites W2094954825 @default.
- W1969901690 cites W2099358137 @default.
- W1969901690 cites W2135327318 @default.
- W1969901690 cites W2137225997 @default.
- W1969901690 cites W2144333355 @default.
- W1969901690 cites W2144545093 @default.
- W1969901690 cites W2157873615 @default.
- W1969901690 cites W2161725950 @default.
- W1969901690 cites W2162379251 @default.
- W1969901690 cites W2174766477 @default.
- W1969901690 cites W2342309721 @default.
- W1969901690 cites W2409677356 @default.
- W1969901690 cites W293972618 @default.
- W1969901690 cites W4313310715 @default.
- W1969901690 cites W4313315112 @default.
- W1969901690 doi "https://doi.org/10.1002/eji.1830240627" @default.
- W1969901690 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7911423" @default.
- W1969901690 hasPublicationYear "1994" @default.
- W1969901690 type Work @default.
- W1969901690 sameAs 1969901690 @default.
- W1969901690 citedByCount "32" @default.
- W1969901690 countsByYear W19699016902013 @default.
- W1969901690 countsByYear W19699016902014 @default.
- W1969901690 countsByYear W19699016902016 @default.
- W1969901690 countsByYear W19699016902019 @default.
- W1969901690 countsByYear W19699016902021 @default.
- W1969901690 countsByYear W19699016902022 @default.
- W1969901690 crossrefType "journal-article" @default.
- W1969901690 hasAuthorship W1969901690A5002675485 @default.
- W1969901690 hasAuthorship W1969901690A5035536310 @default.
- W1969901690 hasAuthorship W1969901690A5050552080 @default.
- W1969901690 hasConcept C104317684 @default.
- W1969901690 hasConcept C135763542 @default.
- W1969901690 hasConcept C147483822 @default.
- W1969901690 hasConcept C153911025 @default.
- W1969901690 hasConcept C159047783 @default.
- W1969901690 hasConcept C19317047 @default.
- W1969901690 hasConcept C195616568 @default.
- W1969901690 hasConcept C197754878 @default.
- W1969901690 hasConcept C203014093 @default.
- W1969901690 hasConcept C207936829 @default.
- W1969901690 hasConcept C2776090121 @default.
- W1969901690 hasConcept C2778048844 @default.
- W1969901690 hasConcept C2778371730 @default.
- W1969901690 hasConcept C2781074509 @default.
- W1969901690 hasConcept C54355233 @default.