FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969903089> ?p ?o ?g. }

• W1969903089 endingPage "68" @default.
• W1969903089 startingPage "61" @default.
• W1969903089 abstract "The desmopressin test has been proposed as a useful tool for the differential diagnosis of Cushing's disease. The aim of our study was to investigate, in a large series of patients with Cushing's disease, the incidence of a positive ACTH and cortisol response to desmopressin. Moreover, we repeated the test soon after surgery to verify its usefulness in the assessment of early and late surgical results.One hundred and seven consecutive patients with Cushing's disease, 89 female and 18 male patients, with a mean age of 37.2 +/- 1.3 years, were studied. All patients, except three, repeated the test 5-6 days after surgery. Desmopressin (10 microg) was injected i.v. and blood samples were drawn 15, 30, 45 and 60 minutes thereafter. Plasma ACTH and serum cortisol were measured in duplicate by commercially available immunoassays. A positive response to desmopressin was considered to be a plasma ACTH and serum cortisol increment of at least 30% and 20% above baseline, respectively.Mean basal plasma ACTH level was 17.3 +/- 1.7 pmol/l and rose to a peak level of 42.7 +/- 4.9 pmol/l at 15 minutes Mean basal serum cortisol level was 574 +/- 19 nmol/l and rose to a peak level of 814 +/- 28 nmol/l at 45 minutes. ACTH and cortisol incremental changes were inversely correlated with their respective basal levels. Ninety patients (84.1%) had an ACTH and 84 patients (78.5%) had a cortisol response to desmopressin. Several clinical and demographic characteristics were not significantly different among desmopressin responders and non responders, except that basal ACTH and cortisol levels were significantly higher in desmopressin non responders (27.2 +/- 8.3 pmol/l, 781 +/- 86 nmol/l) than in desmopressin responders (15.4 +/- 1.2 pmol/l, 535 +/- 14 nmol/l). Disappearance of the ACTH and cortisol response to desmopressin after surgery occurred in 50 of 87 (57%) ACTH responders and in 57 of 81 (70.4%) cortisol responders, respectively. However, concordance between the desmopressin test and surgical outcome was not complete. Indeed, 18 patients considered in remission still showed an ACTH increase after desmopressin and, on the contrary, four patients with disappearance of the ACTH response had persistence of hypercortisolism. During follow-up monitoring, three patients, who had persistence of the ACTH response to desmopressin, relapsed 24, 38 and 54 months after surgery.Desmopressin administration elicits a significant rise in ACTH and cortisol levels in the majority but not all patients with Cushing's disease. There is a good, but not complete, concordance between the response to the desmopressin test and the surgical outcome. Our preliminary data show that persistence of the ACTH response to desmopressin in the early postoperative period might be associated with a higher risk of late relapse." @default.
• W1969903089 created "2016-06-24" @default.
• W1969903089 creator A5002524159 @default.
• W1969903089 creator A5009828573 @default.
• W1969903089 creator A5034965594 @default.
• W1969903089 creator A5042420012 @default.
• W1969903089 creator A5056646554 @default.
• W1969903089 creator A5065788635 @default.
• W1969903089 creator A5079923997 @default.
• W1969903089 date "2001-07-01" @default.
• W1969903089 modified "2023-10-18" @default.
• W1969903089 title "Desmopressin stimulation test before and after pituitary surgery in patients with Cushing's disease" @default.
• W1969903089 cites W1549512600 @default.
• W1969903089 cites W156663091 @default.
• W1969903089 cites W1969851111 @default.
• W1969903089 cites W1973963780 @default.
• W1969903089 cites W1992503589 @default.
• W1969903089 cites W2000696168 @default.
• W1969903089 cites W2005168224 @default.
• W1969903089 cites W2009604097 @default.
• W1969903089 cites W2011181656 @default.
• W1969903089 cites W2012694446 @default.
• W1969903089 cites W2017027985 @default.
• W1969903089 cites W2029573206 @default.
• W1969903089 cites W2031738256 @default.
• W1969903089 cites W2049747166 @default.
• W1969903089 cites W2061219598 @default.
• W1969903089 cites W2064899090 @default.
• W1969903089 cites W2065437604 @default.
• W1969903089 cites W2069799451 @default.
• W1969903089 cites W2074093250 @default.
• W1969903089 cites W2078832051 @default.
• W1969903089 cites W2104855184 @default.
• W1969903089 cites W2114001827 @default.
• W1969903089 cites W2130043659 @default.
• W1969903089 cites W2170433618 @default.
• W1969903089 cites W4243957564 @default.
• W1969903089 cites W4244379378 @default.
• W1969903089 cites W4247130023 @default.
• W1969903089 cites W4250539282 @default.
• W1969903089 cites W4253704384 @default.
• W1969903089 cites W4255718992 @default.
• W1969903089 doi "https://doi.org/10.1046/j.1365-2265.2001.01324.x" @default.
• W1969903089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11453953" @default.
• W1969903089 hasPublicationYear "2001" @default.
• W1969903089 type Work @default.
• W1969903089 sameAs 1969903089 @default.
• W1969903089 citedByCount "65" @default.
• W1969903089 countsByYear W19699030892012 @default.
• W1969903089 countsByYear W19699030892013 @default.
• W1969903089 countsByYear W19699030892014 @default.
• W1969903089 countsByYear W19699030892015 @default.
• W1969903089 countsByYear W19699030892016 @default.
• W1969903089 countsByYear W19699030892017 @default.
• W1969903089 countsByYear W19699030892018 @default.
• W1969903089 countsByYear W19699030892019 @default.
• W1969903089 countsByYear W19699030892020 @default.
• W1969903089 countsByYear W19699030892021 @default.
• W1969903089 countsByYear W19699030892022 @default.
• W1969903089 countsByYear W19699030892023 @default.
• W1969903089 crossrefType "journal-article" @default.
• W1969903089 hasAuthorship W1969903089A5002524159 @default.
• W1969903089 hasAuthorship W1969903089A5009828573 @default.
• W1969903089 hasAuthorship W1969903089A5034965594 @default.
• W1969903089 hasAuthorship W1969903089A5042420012 @default.
• W1969903089 hasAuthorship W1969903089A5056646554 @default.
• W1969903089 hasAuthorship W1969903089A5065788635 @default.
• W1969903089 hasAuthorship W1969903089A5079923997 @default.
• W1969903089 hasConcept C126322002 @default.
• W1969903089 hasConcept C134018914 @default.
• W1969903089 hasConcept C2776810848 @default.
• W1969903089 hasConcept C2777428134 @default.
• W1969903089 hasConcept C2778024521 @default.
• W1969903089 hasConcept C2778065167 @default.
• W1969903089 hasConcept C2778702241 @default.
• W1969903089 hasConcept C2778709874 @default.
• W1969903089 hasConcept C2779134260 @default.
• W1969903089 hasConcept C2779318953 @default.
• W1969903089 hasConcept C2779653919 @default.
• W1969903089 hasConcept C2780214960 @default.
• W1969903089 hasConcept C2780546910 @default.
• W1969903089 hasConcept C555293320 @default.
• W1969903089 hasConcept C71315377 @default.
• W1969903089 hasConcept C71924100 @default.
• W1969903089 hasConceptScore W1969903089C126322002 @default.
• W1969903089 hasConceptScore W1969903089C134018914 @default.
• W1969903089 hasConceptScore W1969903089C2776810848 @default.
• W1969903089 hasConceptScore W1969903089C2777428134 @default.
• W1969903089 hasConceptScore W1969903089C2778024521 @default.
• W1969903089 hasConceptScore W1969903089C2778065167 @default.
• W1969903089 hasConceptScore W1969903089C2778702241 @default.
• W1969903089 hasConceptScore W1969903089C2778709874 @default.
• W1969903089 hasConceptScore W1969903089C2779134260 @default.
• W1969903089 hasConceptScore W1969903089C2779318953 @default.
• W1969903089 hasConceptScore W1969903089C2779653919 @default.
• W1969903089 hasConceptScore W1969903089C2780214960 @default.
• W1969903089 hasConceptScore W1969903089C2780546910 @default.
• W1969903089 hasConceptScore W1969903089C555293320 @default.

• next