Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969910109> ?p ?o ?g. }
- W1969910109 endingPage "12" @default.
- W1969910109 startingPage "12" @default.
- W1969910109 abstract "To review current concepts of photodynamic therapy (PDT) applied to the treatment of tumors of the gastrointestinal tract.PDT initially involves the uptake or production of a photosensitive compound by tumor cells. Subsequent activation of the photoreactive compound by a specific wavelength of light results in cell death, either directly or as a result of vascular compromise and/or apoptosis.The authors selectively review current concepts relating to photosensitization, photoactivation, time of PDT application, tissue selectivity, sites of photodynamic action, PDT effects on normal tissue, limitations of PDT, toxicity of photosensitizers, application of principles of PDT to tumor detection, and current applications of PDT to tumors of the gastrointestinal tract.PDT is clearly effective for small cancers, but it is not yet clear in which cases such treatment is more effective than other currently acceptable approaches. The major side effect of PDT is cutaneous photosensitization. The major limitation of PDT is depth of tumor kill. As data from current and future clinical trials become available, a clearer perspective of where PDT fits in the treatment of cancers will be gained. Many issues regarding pharmacokinetic data of photosensitizers, newer technology involved in light sources, optimal treatment regimens that take advantage of the pharmacophysiology of photoablation, and light dosimetry still require solution. One can foresee application of differing sensitizers and light sources depending on the specific clinical situation. As technologic advances occur, interstitial PDT may have significant application.PDT has a potentially important role either as a primary or adjuvant mode of treatment of tumors of the gastrointestinal tract." @default.
- W1969910109 created "2016-06-24" @default.
- W1969910109 creator A5001063598 @default.
- W1969910109 creator A5048175421 @default.
- W1969910109 creator A5051904313 @default.
- W1969910109 creator A5080522467 @default.
- W1969910109 date "1999-07-01" @default.
- W1969910109 modified "2023-10-12" @default.
- W1969910109 title "Current Concepts in Gastrointestinal Photodynamic Therapy" @default.
- W1969910109 cites W1485336339 @default.
- W1969910109 cites W1604244229 @default.
- W1969910109 cites W1610046461 @default.
- W1969910109 cites W1714033325 @default.
- W1969910109 cites W1835314517 @default.
- W1969910109 cites W1954387510 @default.
- W1969910109 cites W1964219512 @default.
- W1969910109 cites W1965378211 @default.
- W1969910109 cites W1966497314 @default.
- W1969910109 cites W1966550851 @default.
- W1969910109 cites W1968268490 @default.
- W1969910109 cites W1971881018 @default.
- W1969910109 cites W1972336603 @default.
- W1969910109 cites W1976408966 @default.
- W1969910109 cites W1977707442 @default.
- W1969910109 cites W1980157200 @default.
- W1969910109 cites W1985757402 @default.
- W1969910109 cites W1987046265 @default.
- W1969910109 cites W1988355001 @default.
- W1969910109 cites W1991767819 @default.
- W1969910109 cites W1992128321 @default.
- W1969910109 cites W1992363953 @default.
- W1969910109 cites W1993719158 @default.
- W1969910109 cites W1993725955 @default.
- W1969910109 cites W1994664284 @default.
- W1969910109 cites W1994732126 @default.
- W1969910109 cites W1998735492 @default.
- W1969910109 cites W1999400828 @default.
- W1969910109 cites W2001115630 @default.
- W1969910109 cites W2002246590 @default.
- W1969910109 cites W2002756972 @default.
- W1969910109 cites W2003896342 @default.
- W1969910109 cites W2005467290 @default.
- W1969910109 cites W2007030237 @default.
- W1969910109 cites W2008613456 @default.
- W1969910109 cites W2013474093 @default.
- W1969910109 cites W2014506753 @default.
- W1969910109 cites W2015238900 @default.
- W1969910109 cites W2017363091 @default.
- W1969910109 cites W2017411336 @default.
- W1969910109 cites W2018513196 @default.
- W1969910109 cites W2020065415 @default.
- W1969910109 cites W2025808765 @default.
- W1969910109 cites W2027899498 @default.
- W1969910109 cites W2028625808 @default.
- W1969910109 cites W2030276028 @default.
- W1969910109 cites W2030382564 @default.
- W1969910109 cites W2030892741 @default.
- W1969910109 cites W2032063521 @default.
- W1969910109 cites W2033340708 @default.
- W1969910109 cites W2033853636 @default.
- W1969910109 cites W2035228846 @default.
- W1969910109 cites W2038701673 @default.
- W1969910109 cites W2040262244 @default.
- W1969910109 cites W2042821039 @default.
- W1969910109 cites W2043719306 @default.
- W1969910109 cites W2044096564 @default.
- W1969910109 cites W2044803197 @default.
- W1969910109 cites W2045554954 @default.
- W1969910109 cites W2046220452 @default.
- W1969910109 cites W2046248526 @default.
- W1969910109 cites W2047889682 @default.
- W1969910109 cites W2048018154 @default.
- W1969910109 cites W2050542104 @default.
- W1969910109 cites W2051469923 @default.
- W1969910109 cites W2051784631 @default.
- W1969910109 cites W2054368491 @default.
- W1969910109 cites W2056093826 @default.
- W1969910109 cites W2056864727 @default.
- W1969910109 cites W2058330974 @default.
- W1969910109 cites W2060091488 @default.
- W1969910109 cites W2064993922 @default.
- W1969910109 cites W2065644792 @default.
- W1969910109 cites W2069045457 @default.
- W1969910109 cites W2070524517 @default.
- W1969910109 cites W2072182613 @default.
- W1969910109 cites W2072649640 @default.
- W1969910109 cites W2073339937 @default.
- W1969910109 cites W2074518268 @default.
- W1969910109 cites W2074645799 @default.
- W1969910109 cites W2082265629 @default.
- W1969910109 cites W2083489723 @default.
- W1969910109 cites W2085093062 @default.
- W1969910109 cites W2085273292 @default.
- W1969910109 cites W2085315390 @default.
- W1969910109 cites W2085484544 @default.
- W1969910109 cites W2086405807 @default.
- W1969910109 cites W2087384782 @default.
- W1969910109 cites W2090195581 @default.