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• W1969911722 abstract "We investigated the ability of vasoactive intestinal peptide (VIP) to cross the blood-brain barrier (BBB), the interface between the peripheral circulation and central nervous system (CNS). VIP labeled with 131I (I-VIP) and injected intravenously into mice was taken up by brain as determined by multiple-time regression analysis. Excess unlabeled VIP was unable to impede the entry of I-VIP, indicating that passage is by nonsaturable transmembrane diffusion. High pressure liquid chromatography (HPLC) showed the radioactivity entering the brain to be intact I-VIP. After intracerebroventricular (i.c.v.) injection, I-VIP was sequestered by brain, slowing its efflux from the CNS. In summary, VIP crosses the BBB unidirectionally from blood to brain by transmembrane diffusion." @default.
• W1969911722 created "2016-06-24" @default.
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• W1969911722 date "2003-03-01" @default.
• W1969911722 modified "2023-10-17" @default.
• W1969911722 title "Passage of vasoactive intestinal peptide across the blood–brain barrier" @default.
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• W1969911722 doi "https://doi.org/10.1016/s0196-9781(03)00059-7" @default.
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