FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969916858> ?p ?o ?g. }

• W1969916858 endingPage "1086" @default.
• W1969916858 startingPage "1079" @default.
• W1969916858 abstract "A series of anesthetic alcohols inhibited basal and insulin-stimulated 2-deoxy-D-[1-14C]glucose transport in adipocytes over total alcohol concentration ranges that cause local anesthesia of rat sciatic nerve. The relative potencies of the inhibition caused by the alcohols increased in the following order: methanol less than ethanol less than propanol less than butanol less than benzyl alcohol less than hexanol less than octanol. The inhibition was reversible and correlated well with the known partitioning of the alcohols into lipids of biological membranes. Adipocyte membranes were labeled with the 5-nitroxide stearate spin probe to investigate the effects of the alcohols on the dynamic structure of membrane lipids of the adipocyte. The alcohols increased the membrane fluidity, and the relative concentration dependence of the effects closely paralleled that noted from methanol to octanol in transport studies. Alcohols from methanol to hexanol caused inhibition of hexose transport at molar potencies comparable to that observed for membrane disordering. This suggests that hydrophobic regions of the transporter and its lipid environment are perturbed by a comparable mechanism for each alcohol. The cholesterol-complexing polyene antibiotic filipin inhibited hexose transport and influenced the mobility of lipid domains sampled with the nitroxide cholestane, cholesterol-like spin probe. The data are consistent with the concept that the membrane structural/functional effects are mediated by formation of 1:1 cholesterol:filipin complexes. Alcohols and filipin inhibited inherent transporter activity and perturbed the membrane lipid structure without dramatically diminishing transport stimulation by insulin above basal. The specific organization of membrane lipids (particularly cholesterol) may provide an essential environment for optimal transport system activity." @default.
• W1969916858 created "2016-06-24" @default.
• W1969916858 creator A5018176115 @default.
• W1969916858 creator A5025174267 @default.
• W1969916858 creator A5074027925 @default.
• W1969916858 creator A5079063729 @default.
• W1969916858 date "1985-04-01" @default.
• W1969916858 modified "2023-09-27" @default.
• W1969916858 title "Sensitivity of adipocyte basal and insulin-stimulated hexose transport to the membrane lipid structure" @default.
• W1969916858 cites W13381064 @default.
• W1969916858 cites W1508811377 @default.
• W1969916858 cites W1511183935 @default.
• W1969916858 cites W1513838652 @default.
• W1969916858 cites W1517972603 @default.
• W1969916858 cites W1583024484 @default.
• W1969916858 cites W1967298910 @default.
• W1969916858 cites W1970317019 @default.
• W1969916858 cites W1975765488 @default.
• W1969916858 cites W1986054062 @default.
• W1969916858 cites W1993043120 @default.
• W1969916858 cites W1996018474 @default.
• W1969916858 cites W1997458252 @default.
• W1969916858 cites W2003063530 @default.
• W1969916858 cites W2015818124 @default.
• W1969916858 cites W2019401896 @default.
• W1969916858 cites W2023161835 @default.
• W1969916858 cites W2027118206 @default.
• W1969916858 cites W2027811831 @default.
• W1969916858 cites W2040343686 @default.
• W1969916858 cites W2046138267 @default.
• W1969916858 cites W2051989261 @default.
• W1969916858 cites W2052355860 @default.
• W1969916858 cites W2054246775 @default.
• W1969916858 cites W2077094775 @default.
• W1969916858 cites W2078258402 @default.
• W1969916858 cites W2080251500 @default.
• W1969916858 cites W2082410775 @default.
• W1969916858 cites W2082831438 @default.
• W1969916858 cites W2085202527 @default.
• W1969916858 cites W2085336267 @default.
• W1969916858 cites W2094569055 @default.
• W1969916858 cites W2095457013 @default.
• W1969916858 cites W2095919951 @default.
• W1969916858 cites W2276718263 @default.
• W1969916858 cites W2337303981 @default.
• W1969916858 cites W249207201 @default.
• W1969916858 cites W4251494161 @default.
• W1969916858 cites W4296276304 @default.
• W1969916858 doi "https://doi.org/10.1016/0006-2952(85)90612-4" @default.
• W1969916858 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3885956" @default.
• W1969916858 hasPublicationYear "1985" @default.
• W1969916858 type Work @default.
• W1969916858 sameAs 1969916858 @default.
• W1969916858 citedByCount "13" @default.
• W1969916858 crossrefType "journal-article" @default.
• W1969916858 hasAuthorship W1969916858A5018176115 @default.
• W1969916858 hasAuthorship W1969916858A5025174267 @default.
• W1969916858 hasAuthorship W1969916858A5074027925 @default.
• W1969916858 hasAuthorship W1969916858A5079063729 @default.
• W1969916858 hasConcept C107565407 @default.
• W1969916858 hasConcept C122398194 @default.
• W1969916858 hasConcept C12554922 @default.
• W1969916858 hasConcept C134018914 @default.
• W1969916858 hasConcept C161573976 @default.
• W1969916858 hasConcept C171089720 @default.
• W1969916858 hasConcept C181199279 @default.
• W1969916858 hasConcept C185592680 @default.
• W1969916858 hasConcept C2776175234 @default.
• W1969916858 hasConcept C2776393687 @default.
• W1969916858 hasConcept C2779306644 @default.
• W1969916858 hasConcept C2779630084 @default.
• W1969916858 hasConcept C41625074 @default.
• W1969916858 hasConcept C55493867 @default.
• W1969916858 hasConcept C86803240 @default.
• W1969916858 hasConceptScore W1969916858C107565407 @default.
• W1969916858 hasConceptScore W1969916858C122398194 @default.
• W1969916858 hasConceptScore W1969916858C12554922 @default.
• W1969916858 hasConceptScore W1969916858C134018914 @default.
• W1969916858 hasConceptScore W1969916858C161573976 @default.
• W1969916858 hasConceptScore W1969916858C171089720 @default.
• W1969916858 hasConceptScore W1969916858C181199279 @default.
• W1969916858 hasConceptScore W1969916858C185592680 @default.
• W1969916858 hasConceptScore W1969916858C2776175234 @default.
• W1969916858 hasConceptScore W1969916858C2776393687 @default.
• W1969916858 hasConceptScore W1969916858C2779306644 @default.
• W1969916858 hasConceptScore W1969916858C2779630084 @default.
• W1969916858 hasConceptScore W1969916858C41625074 @default.
• W1969916858 hasConceptScore W1969916858C55493867 @default.
• W1969916858 hasConceptScore W1969916858C86803240 @default.
• W1969916858 hasIssue "7" @default.
• W1969916858 hasLocation W19699168581 @default.
• W1969916858 hasLocation W19699168582 @default.
• W1969916858 hasOpenAccess W1969916858 @default.
• W1969916858 hasPrimaryLocation W19699168581 @default.
• W1969916858 hasRelatedWork W1969916858 @default.
• W1969916858 hasRelatedWork W1986054062 @default.
• W1969916858 hasRelatedWork W1992866454 @default.
• W1969916858 hasRelatedWork W2052531890 @default.

• next