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- W1969917845 abstract "Abstract Previous investigations of important factors in lung preservation have stressed the importance of denervation and ischemia as deterimental factors. We believe that lung collapse below the level of functional residual capacity during preservation also decreases the ability of the transplanted lung to provide total pulmonary function. To validate this assumption, four groups of five dogs each were studied utilizing the in vivo isolated lung preparation. This preparation simulates autotransplantation but avoids the attendant time-consuming anastomoses which markedly increase collapse time. In Group I, the isolated ischemic lungs were ventilated for 3 hr with the chest open, thus allowing total collapse of the lung with each respiratory cycle. Subsequently, circulation was restored, the contralateral pulmonary artery was ligated, and the chest was closed for chronic survival. Groups II, III, and IV differed only in that the chest was closed during ischemic periods of 3, 4, and 5 hr, respectively, thus preventing lung collapse below FRC. No dogs survived in Group I. Chronic survivors in Groups II, III, and IV numbered three, two, and one, respectively, supporting the contention that prevention of lung collapse below FRC enhances the ability of lung grafts to assume total respiratory function after implantation. We believe that the prevention of collapse is a much more critical factor in lung preservation than is lung ischemia. So long as collapse time during harvesting, implantation, and the so-called preservation period is less than 30–60 min, one may be able consistently to preserve a lung, under conditions of normothermic ischemia with ventilation above FRC, for 3 hr, with occasional satisfactory preservation up to 5 hr. Failure to minimize lung collapse during the preservation period and during harvesting and implantation may mean the difference between survival and death in lung allograft recipients." @default.
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- W1969917845 date "1973-05-01" @default.
- W1969917845 modified "2023-09-27" @default.
- W1969917845 title "Enhancement of lung preservation by prevention of lung collapse" @default.
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- W1969917845 doi "https://doi.org/10.1016/0022-4804(73)90045-0" @default.
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