FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969923525> ?p ?o ?g. }

• W1969923525 endingPage "472" @default.
• W1969923525 startingPage "462" @default.
• W1969923525 abstract "Coronaviruses contain a positive-sense single-stranded genomic (g) RNA, which encodes nonstructural proteins. Several subgenomic mRNAs (sgmRNAs) encoding structural proteins are generated by template switching from the body transcription regulatory sequence (TRS) to the leader TRS. The process preferentially generates shorter sgmRNA. Appropriate readthrough of body TRSs is required to produce longer sgmRNAs and full-length gRNA. We find that phosphorylation of the viral nucleocapsid (N) by host glycogen synthase kinase-3 (GSK-3) is required for template switching. GSK-3 inhibition selectively reduces the generation of gRNA and longer sgmRNAs, but not shorter sgmRNAs. N phosphorylation allows recruitment of the RNA helicase DDX1 to the phosphorylated-N-containing complex, which facilitates template readthrough and enables longer sgmRNA synthesis. DDX1 knockdown or loss of helicase activity markedly reduces the levels of longer sgmRNAs. Thus, coronaviruses employ a unique strategy for the transition from discontinuous to continuous transcription to ensure balanced sgmRNAs and full-length gRNA synthesis." @default.
• W1969923525 created "2016-06-24" @default.
• W1969923525 creator A5009736513 @default.
• W1969923525 creator A5037531063 @default.
• W1969923525 creator A5058253583 @default.
• W1969923525 date "2014-10-01" @default.
• W1969923525 modified "2023-10-14" @default.
• W1969923525 title "Nucleocapsid Phosphorylation and RNA Helicase DDX1 Recruitment Enables Coronavirus Transition from Discontinuous to Continuous Transcription" @default.
• W1969923525 cites W1522319173 @default.
• W1969923525 cites W1545528913 @default.
• W1969923525 cites W1545952535 @default.
• W1969923525 cites W1598776228 @default.
• W1969923525 cites W1965588691 @default.
• W1969923525 cites W1965907419 @default.
• W1969923525 cites W1990649962 @default.
• W1969923525 cites W1995042237 @default.
• W1969923525 cites W2001222065 @default.
• W1969923525 cites W2011572627 @default.
• W1969923525 cites W2014315807 @default.
• W1969923525 cites W2018705704 @default.
• W1969923525 cites W2023373964 @default.
• W1969923525 cites W2029865102 @default.
• W1969923525 cites W2032639971 @default.
• W1969923525 cites W2035623537 @default.
• W1969923525 cites W2042537644 @default.
• W1969923525 cites W2059265460 @default.
• W1969923525 cites W2076877843 @default.
• W1969923525 cites W2077283045 @default.
• W1969923525 cites W2083412264 @default.
• W1969923525 cites W2090577155 @default.
• W1969923525 cites W2096354888 @default.
• W1969923525 cites W2098443029 @default.
• W1969923525 cites W2105568807 @default.
• W1969923525 cites W2108771986 @default.
• W1969923525 cites W2110524431 @default.
• W1969923525 cites W2111080041 @default.
• W1969923525 cites W2112277337 @default.
• W1969923525 cites W2112564006 @default.
• W1969923525 cites W2113927019 @default.
• W1969923525 cites W2126432031 @default.
• W1969923525 cites W2135951090 @default.
• W1969923525 cites W2138586974 @default.
• W1969923525 cites W2146021974 @default.
• W1969923525 cites W2148419420 @default.
• W1969923525 cites W2151937581 @default.
• W1969923525 cites W2163595857 @default.
• W1969923525 cites W2164319770 @default.
• W1969923525 cites W2165954387 @default.
• W1969923525 cites W2170676593 @default.
• W1969923525 cites W2171197975 @default.
• W1969923525 cites W2171883465 @default.
• W1969923525 cites W2208675311 @default.
• W1969923525 doi "https://doi.org/10.1016/j.chom.2014.09.009" @default.
• W1969923525 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7104987" @default.
• W1969923525 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25299332" @default.
• W1969923525 hasPublicationYear "2014" @default.
• W1969923525 type Work @default.
• W1969923525 sameAs 1969923525 @default.
• W1969923525 citedByCount "155" @default.
• W1969923525 countsByYear W19699235252015 @default.
• W1969923525 countsByYear W19699235252016 @default.
• W1969923525 countsByYear W19699235252017 @default.
• W1969923525 countsByYear W19699235252018 @default.
• W1969923525 countsByYear W19699235252019 @default.
• W1969923525 countsByYear W19699235252020 @default.
• W1969923525 countsByYear W19699235252021 @default.
• W1969923525 countsByYear W19699235252022 @default.
• W1969923525 countsByYear W19699235252023 @default.
• W1969923525 crossrefType "journal-article" @default.
• W1969923525 hasAuthorship W1969923525A5009736513 @default.
• W1969923525 hasAuthorship W1969923525A5037531063 @default.
• W1969923525 hasAuthorship W1969923525A5058253583 @default.
• W1969923525 hasBestOaLocation W19699235251 @default.
• W1969923525 hasConcept C104317684 @default.
• W1969923525 hasConcept C11960822 @default.
• W1969923525 hasConcept C132455925 @default.
• W1969923525 hasConcept C138885662 @default.
• W1969923525 hasConcept C153911025 @default.
• W1969923525 hasConcept C161223559 @default.
• W1969923525 hasConcept C173396325 @default.
• W1969923525 hasConcept C179926584 @default.
• W1969923525 hasConcept C189819185 @default.
• W1969923525 hasConcept C41895202 @default.
• W1969923525 hasConcept C54355233 @default.
• W1969923525 hasConcept C67705224 @default.
• W1969923525 hasConcept C68592252 @default.
• W1969923525 hasConcept C86803240 @default.
• W1969923525 hasConcept C95444343 @default.
• W1969923525 hasConcept C97702854 @default.
• W1969923525 hasConcept C98108389 @default.
• W1969923525 hasConceptScore W1969923525C104317684 @default.
• W1969923525 hasConceptScore W1969923525C11960822 @default.
• W1969923525 hasConceptScore W1969923525C132455925 @default.
• W1969923525 hasConceptScore W1969923525C138885662 @default.
• W1969923525 hasConceptScore W1969923525C153911025 @default.
• W1969923525 hasConceptScore W1969923525C161223559 @default.
• W1969923525 hasConceptScore W1969923525C173396325 @default.
• W1969923525 hasConceptScore W1969923525C179926584 @default.

• next