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• W1969923786 abstract "A series of 231 patients with primary acute pericardial disease (acute pericarditis or tamponade presenting without an apparent cause) were studied according to the following protocol: general clinical and laboratory studies (stage I), pericardiocentesis (stage II), pericardial biopsy (stage III) and blind antituberculous therapy (stage IV). In 32 patients (14%) a specific etiologic diagnosis was obtained (13 with neoplasia, 9 with tuberculosis, 4 with collagen vascular disease, 2 with toxoplasmosis, 2 with purulent pericarditis and 2 with viral pericarditis). Diagnostic pericardiocentesis (32 patients) was performed when clinical activity and effusion persisted for longer than 1 week or when purulent pericarditis was suspected, whereas therapeutic pericardiocentesis (44 patients) was performed to treat tamponade; their diagnostic yield was 6% and 29%, respectively. Diagnostic biopsy (20 patients) was carried out when illness persisted for longer than 3 weeks, whereas therapeutic biopsy was performed whenever pericardiocentesis failed to relieve tamponade; their diagnostic yield was 5% and 54%, respectively. The diagnostic yield difference between diagnostic and therapeutic procedures was significant (p less than 0.001); in contrast, the global diagnostic yield of pericardiocentesis (19%) and biopsy (22%) was similar. At the end of follow-up (1 to 76 months, mean 31 +/- 20), no patient in whom a diagnosis of idiopathic pericarditis had been made showed signs of pericardial disease. It is concluded that a diagnostic procedure is not warranted as a routine method, a choice between therapeutic pericardiocentesis and biopsy is circumstantial and must be individualized, and only through a systematic approach can a substantial diagnostic yield be reached in primary acute pericardial disease." @default.
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• W1969923786 date "1985-10-01" @default.
• W1969923786 modified "2023-10-16" @default.
• W1969923786 title "Primary acute pericardial disease: A prospective series of 231 consecutive patients" @default.
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• W1969923786 doi "https://doi.org/10.1016/0002-9149(85)91023-9" @default.
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