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- W1969926844 abstract "Purpose In a follow-up to a previous study, surface contamination with the antineoplastic drug cyclophosphamide was compared in 30 US hospital pharmacies from 2004 to 2010 following preparation with standard drug preparation techniques or the PhaSeal closed system drug transfer device (CSTD). Methods Wipe samples were taken from biological safety cabinet (BSC) surfaces, BSC airfoils (the front leading edge of the BSC), floors in front of BSCs, and countertops in the pharmacy, and they were analyzed for contamination with cyclophosphamide. Contamination was reassessed after a minimum of 6 months following the implementation of the CSTD. Surface contamination (ng/cm 2 ) was compared between the 2 techniques and between the previous and current test periods and evaluated with the Kruskal-Wallis test. Results With the use of CSTD compared to the standard preparation techniques, a significant reduction in levels of contamination with cyclophosphamide was observed ( P < .0001). Median values for surface contamination with cyclophosphamide were reduced by 86% compared to 95% in the previous study. Conclusions The CSTD significantly reduced, but did not totally eliminate, surface contamination with cyclophosphamide. In addition to other protective measures, increased usage of CSTDs should be employed to help protect health care workers from exposure to hazardous drugs." @default.
- W1969926844 created "2016-06-24" @default.
- W1969926844 creator A5018940636 @default.
- W1969926844 creator A5068521297 @default.
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- W1969926844 date "2013-03-01" @default.
- W1969926844 modified "2023-09-23" @default.
- W1969926844 title "Reduction in Surface Contamination with Cyclophosphamide in 30 US Hospital Pharmacies following Implementation of a Closed-System Drug Transfer Device" @default.
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- W1969926844 doi "https://doi.org/10.1310/hpj4803-204" @default.
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