Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969928253> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W1969928253 abstract "In the search for new therapeutics for the treatment of depression, ethanolic extracts from South African medicinal plants Agapanthus campanulatus F.M. Leighton (Alliaceae) (AC), Boophane distica (L.f.) herb (Amarylliaceae), (BD), Mondia whitei (Hook.f.) Skeels (Asclepiadeace) (MW) and Xysmalobium undulatum (L.) Aiton.f. (Asclepiadeace) (XU) used in traditional medicine to treat mental illnesses related to depression were investigated. Extracts were tested in in vitro and in vivo models for depression. The extracts were screened for affinity for the serotonin transporter (SERT) in the [3H]-citalopram binding assay. Functional characterization of the extracts was conducted using cloned human SERT, norepinephrine uptake (NET) and dopamineuptake (DAT). Antidepressant-like effects of the extracts were investigated using the tail suspension test (TST) and the forced swim test in both rats (rFST) and mice (mFST). All four plants showed affinity for SERT in the binding assay (figure 1). AC and BD showed functional inhibition of SERT, NET and DAT while MW affected SERT and XU showed no effect. BD showed significant effect in the TST (125mg/kg) and in the rFST/mFST (250–500mg/kg), AC showed significant effect in mFST (250–500mg/kg), MW showed significant effect in the rFST (250mg/kg) and XU showed significant effect in the mFST (250–500mg/kg). In conclusion, all four plants exhibited in vitro and in vivo antidepressant-like effects, which supports their traditional use." @default.
- W1969928253 created "2016-06-24" @default.
- W1969928253 creator A5016599557 @default.
- W1969928253 creator A5017334559 @default.
- W1969928253 creator A5045678056 @default.
- W1969928253 creator A5047198686 @default.
- W1969928253 creator A5054098103 @default.
- W1969928253 creator A5082517862 @default.
- W1969928253 creator A5087221328 @default.
- W1969928253 creator A5088582956 @default.
- W1969928253 creator A5090499212 @default.
- W1969928253 date "2008-07-01" @default.
- W1969928253 modified "2023-09-27" @default.
- W1969928253 title "Effects of South Africa traditional medicine in animal models of depression" @default.
- W1969928253 doi "https://doi.org/10.1055/s-0028-1084244" @default.
- W1969928253 hasPublicationYear "2008" @default.
- W1969928253 type Work @default.
- W1969928253 sameAs 1969928253 @default.
- W1969928253 citedByCount "0" @default.
- W1969928253 crossrefType "journal-article" @default.
- W1969928253 hasAuthorship W1969928253A5016599557 @default.
- W1969928253 hasAuthorship W1969928253A5017334559 @default.
- W1969928253 hasAuthorship W1969928253A5045678056 @default.
- W1969928253 hasAuthorship W1969928253A5047198686 @default.
- W1969928253 hasAuthorship W1969928253A5054098103 @default.
- W1969928253 hasAuthorship W1969928253A5082517862 @default.
- W1969928253 hasAuthorship W1969928253A5087221328 @default.
- W1969928253 hasAuthorship W1969928253A5088582956 @default.
- W1969928253 hasAuthorship W1969928253A5090499212 @default.
- W1969928253 hasConcept C126322002 @default.
- W1969928253 hasConcept C136569192 @default.
- W1969928253 hasConcept C150903083 @default.
- W1969928253 hasConcept C202751555 @default.
- W1969928253 hasConcept C207001950 @default.
- W1969928253 hasConcept C2779177272 @default.
- W1969928253 hasConcept C2781001258 @default.
- W1969928253 hasConcept C2781161787 @default.
- W1969928253 hasConcept C55493867 @default.
- W1969928253 hasConcept C556039675 @default.
- W1969928253 hasConcept C71924100 @default.
- W1969928253 hasConcept C86803240 @default.
- W1969928253 hasConcept C98274493 @default.
- W1969928253 hasConceptScore W1969928253C126322002 @default.
- W1969928253 hasConceptScore W1969928253C136569192 @default.
- W1969928253 hasConceptScore W1969928253C150903083 @default.
- W1969928253 hasConceptScore W1969928253C202751555 @default.
- W1969928253 hasConceptScore W1969928253C207001950 @default.
- W1969928253 hasConceptScore W1969928253C2779177272 @default.
- W1969928253 hasConceptScore W1969928253C2781001258 @default.
- W1969928253 hasConceptScore W1969928253C2781161787 @default.
- W1969928253 hasConceptScore W1969928253C55493867 @default.
- W1969928253 hasConceptScore W1969928253C556039675 @default.
- W1969928253 hasConceptScore W1969928253C71924100 @default.
- W1969928253 hasConceptScore W1969928253C86803240 @default.
- W1969928253 hasConceptScore W1969928253C98274493 @default.
- W1969928253 hasIssue "09" @default.
- W1969928253 hasLocation W19699282531 @default.
- W1969928253 hasOpenAccess W1969928253 @default.
- W1969928253 hasPrimaryLocation W19699282531 @default.
- W1969928253 hasRelatedWork W1964192948 @default.
- W1969928253 hasRelatedWork W1980855166 @default.
- W1969928253 hasRelatedWork W2031210349 @default.
- W1969928253 hasRelatedWork W2046033957 @default.
- W1969928253 hasRelatedWork W2083379681 @default.
- W1969928253 hasRelatedWork W2114795231 @default.
- W1969928253 hasRelatedWork W2353197136 @default.
- W1969928253 hasRelatedWork W2407457728 @default.
- W1969928253 hasRelatedWork W2900331496 @default.
- W1969928253 hasRelatedWork W2903479428 @default.
- W1969928253 hasVolume "74" @default.
- W1969928253 isParatext "false" @default.
- W1969928253 isRetracted "false" @default.
- W1969928253 magId "1969928253" @default.
- W1969928253 workType "article" @default.