FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969935384> ?p ?o ?g. }

• W1969935384 endingPage "770" @default.
• W1969935384 startingPage "760" @default.
• W1969935384 abstract "Abstract The amide proton transfer (APT) effect has emerged as a unique endogenous molecular imaging contrast mechanism with great clinical potentials. However, in vivo quantitative mapping of APT using the conventional asymmetry analysis is difficult due to the confounding nuclear Overhauser effect (NOE) and the asymmetry of the magnetization transfer effect. Here, we showed that the asymmetry of magnetization transfer contrast from immobile macromolecules is highly significant, and the wide spectral separation associated with a high magnetic field of 9.4 T delineates APT and NOE peaks in a Z‐spectrum. Therefore, high‐resolution apparent APT and NOE maps can be obtained from measurements at three offsets. The apparent APT value was greater in gray matter compared to white matter in normal rat brain and was sensitive to tissue acidosis and correlated well with apparent diffusion coefficient in the rat focal ischemic brain. In contrast, no ischemia‐induced contrast was observed in the apparent NOE map. The concentration dependence and the pH insensitivity of NOE were confirmed in phantom experiments. Our results demonstrate that in vivo apparent APT and NOE maps can be easily obtained at high magnetic fields and the pH‐insensitive NOE may be a useful indicator of mobile macromolecular contents. Magn Reson Med, 2013. © 2012 Wiley Periodicals, Inc." @default.
• W1969935384 created "2016-06-24" @default.
• W1969935384 creator A5005721773 @default.
• W1969935384 creator A5013736647 @default.
• W1969935384 creator A5059535270 @default.
• W1969935384 creator A5090522721 @default.
• W1969935384 date "2012-05-10" @default.
• W1969935384 modified "2023-10-13" @default.
• W1969935384 title "MR imaging of the amide‐proton transfer effect and the pH‐insensitive nuclear overhauser effect at 9.4 T" @default.
• W1969935384 cites W1967800362 @default.
• W1969935384 cites W1979332341 @default.
• W1969935384 cites W1984317687 @default.
• W1969935384 cites W1987114126 @default.
• W1969935384 cites W1995721991 @default.
• W1969935384 cites W1996911308 @default.
• W1969935384 cites W2012678826 @default.
• W1969935384 cites W2013982365 @default.
• W1969935384 cites W2014783107 @default.
• W1969935384 cites W2016047802 @default.
• W1969935384 cites W2016903968 @default.
• W1969935384 cites W2022593257 @default.
• W1969935384 cites W2039659420 @default.
• W1969935384 cites W2044507925 @default.
• W1969935384 cites W2045446885 @default.
• W1969935384 cites W2048919807 @default.
• W1969935384 cites W2053999722 @default.
• W1969935384 cites W2054130199 @default.
• W1969935384 cites W2054131761 @default.
• W1969935384 cites W2056291378 @default.
• W1969935384 cites W2064588148 @default.
• W1969935384 cites W2066475056 @default.
• W1969935384 cites W2066520774 @default.
• W1969935384 cites W2070231190 @default.
• W1969935384 cites W2072418533 @default.
• W1969935384 cites W2072510712 @default.
• W1969935384 cites W2074034549 @default.
• W1969935384 cites W2074136578 @default.
• W1969935384 cites W2081626096 @default.
• W1969935384 cites W2083589103 @default.
• W1969935384 cites W2092155503 @default.
• W1969935384 cites W2092996352 @default.
• W1969935384 cites W2093263093 @default.
• W1969935384 cites W2098119564 @default.
• W1969935384 cites W2130735928 @default.
• W1969935384 cites W2138015234 @default.
• W1969935384 cites W2148518504 @default.
• W1969935384 doi "https://doi.org/10.1002/mrm.24315" @default.
• W1969935384 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3419318" @default.
• W1969935384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22577042" @default.
• W1969935384 hasPublicationYear "2012" @default.
• W1969935384 type Work @default.
• W1969935384 sameAs 1969935384 @default.
• W1969935384 citedByCount "218" @default.
• W1969935384 countsByYear W19699353842013 @default.
• W1969935384 countsByYear W19699353842014 @default.
• W1969935384 countsByYear W19699353842015 @default.
• W1969935384 countsByYear W19699353842016 @default.
• W1969935384 countsByYear W19699353842017 @default.
• W1969935384 countsByYear W19699353842018 @default.
• W1969935384 countsByYear W19699353842019 @default.
• W1969935384 countsByYear W19699353842020 @default.
• W1969935384 countsByYear W19699353842021 @default.
• W1969935384 countsByYear W19699353842022 @default.
• W1969935384 countsByYear W19699353842023 @default.
• W1969935384 crossrefType "journal-article" @default.
• W1969935384 hasAuthorship W1969935384A5005721773 @default.
• W1969935384 hasAuthorship W1969935384A5013736647 @default.
• W1969935384 hasAuthorship W1969935384A5059535270 @default.
• W1969935384 hasAuthorship W1969935384A5090522721 @default.
• W1969935384 hasBestOaLocation W19699353841 @default.
• W1969935384 hasConcept C119851462 @default.
• W1969935384 hasConcept C121332964 @default.
• W1969935384 hasConcept C126838900 @default.
• W1969935384 hasConcept C143409427 @default.
• W1969935384 hasConcept C150903083 @default.
• W1969935384 hasConcept C185592680 @default.
• W1969935384 hasConcept C207001950 @default.
• W1969935384 hasConcept C2781192897 @default.
• W1969935384 hasConcept C27826641 @default.
• W1969935384 hasConcept C38976095 @default.
• W1969935384 hasConcept C46141821 @default.
• W1969935384 hasConcept C62520636 @default.
• W1969935384 hasConcept C66974803 @default.
• W1969935384 hasConcept C71924100 @default.
• W1969935384 hasConcept C86803240 @default.
• W1969935384 hasConceptScore W1969935384C119851462 @default.
• W1969935384 hasConceptScore W1969935384C121332964 @default.
• W1969935384 hasConceptScore W1969935384C126838900 @default.
• W1969935384 hasConceptScore W1969935384C143409427 @default.
• W1969935384 hasConceptScore W1969935384C150903083 @default.
• W1969935384 hasConceptScore W1969935384C185592680 @default.
• W1969935384 hasConceptScore W1969935384C207001950 @default.
• W1969935384 hasConceptScore W1969935384C2781192897 @default.
• W1969935384 hasConceptScore W1969935384C27826641 @default.
• W1969935384 hasConceptScore W1969935384C38976095 @default.
• W1969935384 hasConceptScore W1969935384C46141821 @default.
• W1969935384 hasConceptScore W1969935384C62520636 @default.
• W1969935384 hasConceptScore W1969935384C66974803 @default.

• next